FGFR1-Binding Polypeptide for Stable Skin and Mucosal Repair
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Solution Overview
Problem
Existing treatments for skin and mucosal injuries, particularly those associated with acute and chronic gastrointestinal diseases and tumors, are limited by the high cost and instability of long amino acid sequence proteins/polypeptides, and there is a need for more effective and stable peptide substances.
Innovation Solution
A polypeptide that binds to FGFR1, inhibiting or promoting cell proliferation, vascular proliferation, and collagen formation by blocking or activating FGF/FGFR1 signaling, with specific amino acid sequences such as Ser-Met-Gln-Ala-Ser-Leu-Glu-Ala-Glu-Ala-Lys-Gly-Lys-Ala-Glu, is developed to address these issues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If long amino acid sequence proteins/polypeptides are used for wound healing, then wound healing effect is improved, but preparation cost increases and stability deteriorates
Solution Approach 1:
The patent extracts the essential functional domain from long amino acid sequence proteins by identifying and isolating the specific peptide sequence that binds to FGFR1. Instead of using complete long proteins, the invention uses a truncated peptide (e.g., 15-20 amino acids) that retains the key binding functionality while eliminating the instability and high cost associated with full-length proteins.
Solution Approach 2:
The patent segments the long amino acid sequence protein into smaller functional units by identifying the critical binding region. The full-length protein is divided such that only the essential FGFR1-binding peptide sequence is retained for therapeutic use, while non-essential portions are removed. This segmentation creates a stable, cost-effective peptide that maintains therapeutic efficacy.
2Reliability
If long amino acid sequence proteins/polypeptides are used for wound healing, then wound healing effect is improved, but preparation cost increases
Solution Approach 1:
The invention extracts only the essential FGFR1-binding peptide sequence from long proteins, dramatically reducing the number of amino acids that need to be synthesized. This extraction approach lowers preparation costs by reducing raw material requirements, simplifying synthesis processes, and decreasing purification complexity while maintaining therapeutic wound healing effects.
3Reliability
If FGF/FGFR1 signaling is activated to promote tissue repair, then cell proliferation and tissue regeneration are improved, but tumor growth risk increases
Solution Approach 1:
The patent uses a carefully designed peptide as an intermediary that selectively activates FGF/FGFR1 signaling in specific contexts. The peptide acts as a controlled mediator that can promote tissue repair in damaged areas without causing uncontrolled cell proliferation. By using a truncated peptide rather than full-length FGF, the signaling is more localized and controllable, reducing the risk of promoting tumor growth while maintaining beneficial tissue regeneration effects.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The polypeptide effectively alleviates pathological development, promotes repair of skin and mucosal damage, treats tumors, and modulates immune functions, with stability and cost-effectiveness, and can be administered orally or topically, maintaining functionality even after disinfection.
Implementation Method 1
the polypeptide of the present invention can bind with receptor FGFR1, and inhibit or promote cell proliferation, vascular proliferation, collagen formation, etc., by blocking or activating FGF/FGFR1 signaling
Data Source
AI summary
A polypeptide for repairing a skin wound or a mucosal injury, having obvious effects of alleviating the pathological development of acute and chronic gastrointestinal diseases, promoting repair of a skin wound or a mucosal injury, treating tumors, etc.; and use of the polypeptide in repairing a skin wound or a mucosal injury. By blocking or activating FGF/FGFR1 signaling, the polypeptide capable of binding to an FGFR1 receptor is capable of inhibiting or promoting cell proliferation, vascular hyperplasia, collagen formation, etc.