Fiber-Enhanced Liposome Stability Against Aggregation

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Solution Overview

Problem

Conventional liposomes suffer from aggregation, flocculation, fusion, and coalescence, leading to instability and rapid clearance of encapsulated agents, and are prone to degradation when dried, losing their structural integrity and effectiveness.

Innovation Solution

Integration of fiber into the liposome structure enhances physical and chemical stability, preventing aggregation and allowing for the creation of stable powdered formulations that maintain integrity and bioavailability of encapsulated agents.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional liposomes are used to encapsulate active agents, then delivery and transport through gut membrane is improved, but aggregation, flocculation, fusion and coalescence occur leading to rapid clearance and loss of stability

Engineering Contradiction:

Improvestability of liposome formulationVSAvoidcirculation time of encapsulated agents

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent combines phospholipids with fiber materials (such as cellulose, hemicellulose, pectin, or chitin) to create a composite liposome structure. The fiber components form a structural framework that reinforces the phospholipid bilayer, preventing aggregation, flocculation, fusion and coalescence while maintaining the liposome's ability to encapsulate and deliver active agents through the gut membrane.

Inventive Principle:

Principle #40Composite materials

2Reliability

If liposomes are stored in hydrated form, then encapsulated agents are protected from degradation, but liposomes become weak and subject to breakage

Engineering Contradiction:

Improveprotection of encapsulated agentsVSAvoidstructural strength of liposomes

Core Design Contradiction:

ReliabilityVSStrength

Solution Approach 1:

The fiber components in the composite liposome structure provide mechanical reinforcement to the phospholipid bilayer. This reinforcement maintains structural integrity and resistance to breakage while the liposome remains in hydrated form, allowing the encapsulated agents to be protected from degradation without sacrificing structural strength.

Inventive Principle:

Principle #40Composite materials

3Reliability

If conventional liposomes are dried to avoid degradation, then storage stability is improved, but liposomes collapse and lose integrity

Engineering Contradiction:

Improvestorage stability of liposomesVSAvoidintegrity of liposome structure

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The fiber materials form a rigid structural framework that maintains liposome integrity during drying processes. Unlike conventional phospholipid-only liposomes that collapse when water is removed, the fiber-reinforced composite structure prevents collapse and maintains the liposomal morphology, allowing for stable powdered formulations that can be reconstituted later.

Inventive Principle:

Principle #40Composite materials

4Reliability

If fiber is integrated into liposome structure, then physical and chemical stability is enhanced, but device complexity increases

Engineering Contradiction:

Improvephysical and chemical stabilityVSAvoidstructural complexity of liposome

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent integrates fiber materials into the liposome structure to create a composite formulation that enhances physical and chemical stability. The fiber components form a structural framework that prevents aggregation, flocculation, fusion and coalescence, while the overall liposome structure remains compatible with existing delivery systems and manufacturing processes.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The fiber-enhanced liposomes exhibit improved stability, sustained release profiles, and enhanced bioavailability of encapsulated agents, including vitamins and drugs, with prolonged absorption and reduced degradation, even in aqueous environments.

Implementation Method 1

integration of fiber into the liposome structure enhances physical and chemical stability, preventing aggregation

Methodology Applied

Scientific EffectPhysical reinforcement through fiber integration:

Implementation Method 2

Liposomes can encapsulate and transport both hydrophilic agents and hydrophobic agents through the gut membrane

Methodology Applied

Scientific EffectEncapsulation:

Implementation Method 3

biodegradable lipid molecules can improve transcellular transport via transient disruption of cellular lipophilic bilayers

Methodology Applied

Scientific EffectTranscellular transport:

Implementation Method 4

may well enhance paracellular drug transport

Methodology Applied

Scientific EffectParacellular transport:

Data Source

PatentUS20240374560A1Fiber-enhanced liposome and methods

Publication Date: 2024.11.14 VIDYA HERBS INC

AI summary

The invention provides a liposome with integrated dietary fiber. The inventive liposome has improved stability, strength, encapsulation and delivery properties for hydrophobic and hydrophilic agents. The integrated dietary fiber permits the liposome to be dried for enhanced storage stability without compromising liposome integrity, strength, shape or surface smoothness due to the loss of water. Methods of making and using the inventive liposome for the delivery of active agents are also contemplated by the invention.