Fiber-Probiotic Composition for Gut Cholesterol Regulation
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Solution Overview
Problem
There is a need to regulate the association of gut bacteria with cholesterol levels in the blood to improve cholesterol levels and prevent or treat cardiovascular, circulatory, and nervous system conditions, as these bacteria are impacted by factors like unhealthy diets, antibiotics, medications, infections, and alcohol, leading to metabolic disturbances.
Innovation Solution
A combination of a fiber blend and a probiotic mixture is administered to eliminate the association with LDL cholesterol and promote a positive correlation with HDL cholesterol, targeting specific gut bacteria species.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a combination of fiber blend and probiotic mixture is administered, then cholesterol levels are improved and gut bacteria association with cholesterol is regulated, but the complexity of the composition and administration protocol increases
Solution Approach 1:
The patent combines fiber blend and probiotic mixture into a single integrated composition that can be administered together. The fiber components (soluble and insoluble) are merged with specific probiotic strains (Lactobacillus acidophilus, Bifidobacterium lactis, Lactobacillus rhamnosus, Bifidobacterium longum, Lactobacillus plantarum, and Bifidobacterium bifidum) to create a unified therapeutic product that regulates gut bacteria and cholesterol levels simultaneously.
Solution Approach 2:
The composition serves multiple functions: it provides both prebiotic fiber components that feed beneficial bacteria and probiotic components that directly introduce beneficial strains. This multi-functional approach addresses cholesterol regulation, gut microbiota modulation, and overall metabolic health through a single administration, reducing the need for multiple separate interventions.
2Object-affected harmful factors
If specific gut bacteria are targeted to eliminate association with LDL cholesterol, then cardiovascular risk is reduced, but the precision of bacterial targeting and measurement is required
Solution Approach 1:
The patent targets specific species-level gut bacteria with distinct functional properties. Different probiotic strains are selected to address specific aspects of cholesterol metabolism: Lactobacillus acidophilus for bile acid metabolism, Bifidobacterium lactis for short-chain fatty acid production, Lactobacillus rhamnosus for immune modulation, and others. This species-specific targeting allows precise modulation of local gut bacterial functions that directly impact LDL cholesterol association.
Solution Approach 2:
The composition includes multiple probiotic strains that work synergistically to produce measurable changes in gut microbiota composition and cholesterol metabolism. The fiber components provide feedback signals to the probiotic bacteria, stimulating their growth and activity. This creates a self-regulating system where the gut bacteria respond to fiber substrates and in turn regulate cholesterol levels, with effects that can be measured and monitored.
Data Source
AI summary
A composition containing a combination of at least one fiber and at least one probiotic can be orally administered to a subject in an amount effective to regulate gut bacteria association with cholesterol levels in the blood of the subject. The method can achieve at least one result that is improvement of cholesterol levels in the blood, prevention and/or treatment of cardiovascular, circulatory, endocrine system and/or nervous system conditions and/or diseases.