Fiber-Probiotic Blend for Microbiome Resilience Against High Fat Diets
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Solution Overview
Problem
The resilience of the gut microbiome is compromised by high fat diets low in fiber, leading to dysbiosis and negative health impacts, which existing methods have not effectively addressed.
Innovation Solution
A combination of a fiber blend and a probiotic mixture is administered to enhance microbiome resilience, improving gastrointestinal health by preventing perturbation, managing dysbiosis, and normalizing stool frequency and gut barrier function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Use of energy by moving object
If a high fat diet low in fiber is consumed, then energy density and satiety are improved, but microbiome resilience and gut health deteriorate
Solution Approach 1:
The patent introduces a combination of fiber and probiotic as an intermediary substance that mediates between the high fat diet and the microbiome. The fiber acts as a prebiotic substrate that feeds beneficial bacteria, while the probiotic strains directly contribute to maintaining microbiome resilience. This intermediary combination allows individuals to consume high fat diets while protecting against the harmful effects on microbiome health.
Solution Approach 2:
The patent changes the parameters of the diet by adding specific fiber components (resistant starch, soluble fiber, insoluble fiber) and probiotic strains to the high fat diet. This parameter modification transforms the diet from being purely harmful to being partially beneficial, allowing maintenance of energy density while improving microbiome resilience through the added fiber and probiotic components.
2Quantity of substance
If a high fat diet low in fiber is consumed, then weight management is improved, but dysbiosis and gut barrier function deteriorate
Solution Approach 1:
The fiber-probiotic combination serves as a protective intermediary that prevents the high fat diet from causing dysbiosis. The fiber provides structural support for beneficial bacteria while the probiotic strains directly counteract the dysbiotic effects of high fat consumption, thereby maintaining weight management benefits without the harmful gut microbiome changes.
Solution Approach 2:
The patent converts the harmful effect of high fat diet-induced dysbiosis into a beneficial state by introducing fiber and probiotics. The fiber acts as a food source for beneficial bacteria, and the probiotics directly populate the gut with health-promoting strains, transforming the dysbiotic environment into a more balanced and resilient microbiome that maintains weight management advantages.
3Use of energy by moving object
If a high fat diet low in fiber is consumed, then calorie intake is improved, but intestinal transit and stool frequency deteriorate
Solution Approach 1:
The patent modifies the dietary parameters by incorporating specific fiber types (resistant starch, soluble fiber, insoluble fiber) that directly influence intestinal transit. These fiber components add bulk to stool, improve bowel regularity, and facilitate smoother intestinal transit while allowing high calorie intake from the high fat diet to be maintained.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination significantly improves microbiome resilience, reducing the impact of high fat diets on gut health, maintaining intestinal transit, and preventing endotoxemia, as demonstrated by clinical trial results.
Implementation Method 1
The human gut microbiome is an ecosystem of trillions of bacteria. Throughout life, the gut microbiome is challenged by one or more of unhealthy diet, antibiotics, other medications, infections, intense exercise, or alcohol.
Data Source
AI summary
A composition contains a combination of at least one fiber and at least one probiotic and is formulated for administration to a subject such that the combination of at least one fiber and at least one probiotic enhance resilience of the microbiome in the subject. Preferably the subject is experiencing a microbiome stressor, will experience a microbiome stressor and/or has recently experienced a microbiome stressor, such as one or more of a dietary stressor, antibiotic, other medications, infections, intense exercise, stress, alcohol, travel and combinations thereof; more preferably at least a dietary stressor; most preferably at least a high fat diet, such as a Western high fat diet or a ketogenic diet. The method can achieve at least one result that is (i) prevention or attenuation of perturbation of microbiota; (ii) recovery after perturbation; and (iii) normalization of one or more of stool frequency, intestinal transit, constipation, gut permeability, endotoxemia or gut barrier function.