Fibrin Gel for Residual Stone Fragment Removal
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Solution Overview
Problem
Current surgical techniques for urinary stone lithotripsy, such as RIRS, often leave residual stone fragments due to limitations in instruments and technology, leading to prolonged excretion times and increased risk of stone recurrence, with approximately 20-30% of patients unable to fully clear residual stones.
Innovation Solution
A composition gel comprising fibrinogen, a fibrin stabilizing factor, thrombin, and plasminogen, which forms a fibrin gel that adheres to and can be removed with negative pressure suction or a stone extractor, enhancing stone clearance rates without damaging the urinary system.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If flexible ureteroscope with laser lithotripsy is used, then surgical range and inspection capability are improved, but residual stone fragments remain due to instrument limitations
Solution Approach 1:
The patent introduces a gel as an intermediary substance between the laser lithotripsy process and stone fragment removal. The gel is injected into the renal collecting system to wrap and adhere to stone fragments, enabling complete removal through natural excretion or enhanced clearance, thereby resolving the incompleteness issue without changing the core lithotripsy instrumentation
Solution Approach 2:
The patent changes the physical state and properties of the surgical environment by introducing a gel with specific viscosity, adhesion, and biodegradability parameters. This gel modifies how stone fragments interact with the urinary tract, enabling complete removal while preserving the advantages of flexible ureteroscope surgery
2Object-affected harmful factors
If stone fragments are removed by natural excretion, then no additional trauma is caused, but excretion time is prolonged and stone recurrence risk increases
Solution Approach 1:
The patent applies preliminary action by injecting the gel before stone fragment excretion. The gel wraps the fragments and facilitates their passage through the urinary tract, accelerating natural excretion while preventing stone recurrence. This preliminary intervention reduces both trauma and excretion time by preparing the fragments for smooth passage
Solution Approach 2:
The gel acts as a mediator that facilitates the interaction between stone fragments and the urinary tract environment. It enables faster, trauma-free removal by improving fragment mobility and reducing adhesion to urinary tract walls during the excretion process
3Productivity
If gel is injected to wrap stone fragments, then stone clearance rate is improved, but complexity of surgical procedure increases
Solution Approach 1:
The gel serves as a simple intermediary that can be injected through existing surgical access points. The injection process integrates smoothly into the existing surgical workflow, requiring minimal additional equipment or training while dramatically improving stone clearance rates through the gel's fragment-wrapping and facilitation properties
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The gel achieves a stone clearance rate of over 85% and reduces the risk of postoperative stone recurrence, facilitating efficient removal of small stone fragments and improving surgical outcomes.
Implementation Method 1
A composition gel for removing residual stone fragments after lithotripsy comprises component A and component B, wherein the component A contains fibrinogen and a fibrin stabilizing factor; the component B contains thrombin
Implementation Method 2
removal of the gel adhering to and wrapping the stones is achieved through negative pressure suction applied by the stone extractor
Data Source
AI summary
A composition gel for surgical efficiency improvement of urinary stone lithotripsy and stone fragments removal in renal collecting system includes component A and component B. The component A contains fibrinogen and fibrin stabilizing factors. The component B contains thrombin. Moreover, at least one of the components A and B contains Ca2+, plasminogen and a coloring agent. The composition gel may quickly form plasminogen-containing fibrin gel with color, and certain toughness and plasticity in urine and normal saline environments, may adhere to and wrap stone fragments in such environments, and is removed by negative pressure suction and/or stone basket. The composition gel is suitable for efficiently removing stone fragments which remain after lithotripsy and are unable to be removed by an effective method at present. It has good biosafety, and achieves stone clearance rate of more than 85% without damage to the kidney and surgical instruments. The fibrin gel may be naturally dissolved in urine without the risk of urinary system obstruction.