Fibrin Sealant Stem Cell Wound Healing
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Solution Overview
Problem
Current treatments for chronic wounds are ineffective for up to 50% of wounds lasting over a year, as they fail to stimulate healing to a satisfactory level, necessitating new approaches for enhancing wound healing.
Innovation Solution
A fibrin sealant composition incorporating a fibrinogen complex, thrombin component, and stem/progenitor cells, with a concentration of 1.5 - 2.0 × 10^6 stem/progenitor cells/cm², is developed for topical application to wounds, allowing for enhanced healing and scar reduction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If standard fibrin sealant concentrations are used (higher than 5 mg/ml), then hemostasis and tissue sealing are improved, but cellular migration and tissue regeneration are inhibited
Solution Approach 1:
The patent applies parameter changes by reducing the fibrinogen concentration from standard levels (10-1000 mg/ml) to a specific low range (2-5 mg/ml). This parameter modification creates a balance where the fibrin sealant maintains adequate hemostatic and sealing functions while the reduced density allows improved cellular migration and tissue regeneration, directly resolving the technical contradiction between strength and productivity.
2Productivity
If high concentrations of stem/progenitor cells are applied, then tissue regeneration is enhanced, but wound healing effectiveness decreases for chronic wounds
Solution Approach 1:
The patent applies parameter changes by optimizing the stem/progenitor cell concentration to a specific range (1.5-2.0 × 10^6 cells/cm²) rather than using arbitrarily high concentrations. This precise parameter optimization ensures sufficient tissue regeneration while maintaining reliability for chronic wound healing, resolving the contradiction between productivity and reliability.
3Productivity
If fibrinogen concentration is reduced to 2-5 mg/ml, then cellular migration is improved, but hemostatic strength is reduced
Solution Approach 1:
The patent applies parameter changes by precisely controlling the fibrinogen concentration within the optimal range of 2-5 mg/ml. This parameter optimization achieves a balance point where cellular migration is sufficiently improved while hemostatic strength remains adequate for clinical use, resolving the technical contradiction between productivity and strength.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The fibrin sealant composition effectively accelerates wound healing by promoting cellular migration and tissue regeneration, significantly reducing wound size and improving healing outcomes in both acute and chronic wounds.
Implementation Method 1
a fibrinogen complex (FC) component, a thrombin component... combining a fibrinogen complex (FC) component, thrombin component, a cellular component in admixture
Data Source
AI summary
Provided herein are compositions and methods using stem/progenitor cells in a therapeutic approach for treatment of, or promotion of healing of, acute and chronic wounds.