Fibrin Adhesive Fixation of X-Ray Markers in Vascular Implants
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Solution Overview
Problem
Existing methods for attaching X-ray markers to vascular implants face challenges such as inadequate X-ray visibility, biocompatibility issues, and the risk of premature detachment due to high viscosity adhesives, leading to potential thrombosis and increased thrombosis risk.
Innovation Solution
The use of a bioresorbable fibrin adhesive, comprising a fibrinogen-containing first component, optionally with a thrombin-containing second component, for attaching X-ray markers to vascular implants, allowing for automated assembly and minimizing non-resorbable components, while ensuring a strong bond and preventing overdosing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If high viscosity silicone adhesive is used to attach X-ray markers, then holding force is improved, but dosing precision deteriorates and leakage occurs
Solution Approach 1:
The patent changes the viscosity parameter of the adhesive from high (silicone) to low (fibrinogen-based), enabling precise dosing through small cannulas while maintaining adequate holding force through rapid polymerization and mechanical interlocking in the eyelet geometry
Solution Approach 2:
The patent uses a bioresorbable adhesive that degrades over time, replacing the need for permanent non-resorbable adhesives. This allows the adhesive to perform its function during the critical early period and then naturally disappear, avoiding long-term complications
2Reliability
If non-resorbable silicone adhesive is used, then biocompatibility is improved, but resorbability deteriorates
Solution Approach 1:
The patent changes the material composition parameter from silicone-based to fibrinogen-based adhesive, transforming it from non-resorbable to bioresorbable while maintaining biocompatibility through the use of natural blood clotting proteins
Solution Approach 2:
The patent creates a composite system combining fibrinogen and thrombin that mimics natural blood clotting, producing a bioresorbable adhesive matrix that is biocompatible and gradually degraded by the body's natural processes
3Reliability
If adhesive amount is increased to prevent premature detachment, then holding force is improved, but thrombosis risk increases
Solution Approach 1:
The patent uses a low viscosity adhesive that can be precisely delivered through hydraulic/dispensing systems through small cannulas, enabling accurate dosing that prevents both premature detachment and excessive adhesive accumulation that could cause thrombosis
Solution Approach 2:
The rapid polymerization of the fibrinogen-thrombin system provides immediate feedback through quick setting, allowing precise control of adhesive amount and placement, preventing both insufficient bonding and excessive dosing that could lead to thrombosis
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method enhances X-ray visibility, reduces the risk of premature marker detachment, and promotes biocompatibility, facilitating automated assembly with improved safety and reduced thrombosis risk.
Implementation Method 1
gluing the X-ray marker into the opening of the medical implant with a liquid adhesive which includes at least one first component including a fibrinogen
Data Source
AI summary
A method for connecting an X-ray marker to a medical implant includes providing a medical implant having an opening for receiving the X-ray marker. An X-ray marker is provided. The X-ray marker is glued into the opening with a liquid adhesive that includes at least one first component including a fibrinogen.