Fibrinogen-Based Tissue Adhesive Patch
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing tissue sealants rely heavily on fibrinogen for both adhesion and coagulation, requiring large quantities and often incorporating fibrinogen as a free powder, which is inefficient and not fully integrated into the film.
Innovation Solution
A fibrinogen-based tissue adhesive patch with a biocompatible polymer film incorporating fibrinogen, thrombin, and CaCl2, where the fibrinogen sealant is physically integrated into the polymer film, eliminating the need for a mesh or woven components and providing a non-permeable, efficient sealing mechanism.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If fibrinogen is used as a free powder to support the hemostatic function, then the coagulant effect is achieved, but the fibrinogen is not fully integrated into the film and requires large quantities
Solution Approach 1:
The patent combines the polymer film and fibrinogen sealant into a single integrated patch structure. The fibrinogen is incorporated into the polymer matrix during manufacturing, creating a unified device where the film and coagulant function together as one system rather than separate components
Solution Approach 2:
The invention creates a composite material by integrating fibrinogen within a polymer matrix. This composite structure allows the polymer to provide structural support and delivery mechanism while the fibrinogen provides hemostatic function, with both components working synergistically in a single material system
2Stability of the object's composition
If a backing is used to support the fibrinogen, then the fibrinogen is stabilized, but the backing is not the primary tissue sealing component
Solution Approach 1:
The patent merges the backing and active sealant components into a single integrated patch. The polymer film itself serves as both the structural backing and the delivery mechanism for the fibrinogen, eliminating the need for separate backing layers while maintaining stability and functionality
Solution Approach 2:
The polymer film performs multiple functions simultaneously: it provides structural support as a backing, serves as a delivery vehicle for the fibrinogen, and acts as the primary tissue sealing component. This multi-functional design eliminates the need for specialized separate components
3Adaptability or versatility
If fibrinogen and thrombin are incorporated into the polymer film, then the adhesion and sealing functions are integrated, but the manufacturing process becomes more complex
Solution Approach 1:
The fibrinogen and thrombin are incorporated into the polymer film during the manufacturing process rather than being added later. This preliminary incorporation ensures proper distribution and integration of the coagulant components within the matrix before the patch is used, simplifying the overall device assembly
Solution Approach 2:
The patent utilizes changes in polymer physical state (melting and solidification) during manufacturing to incorporate the fibrinogen sealant. By heating the polymer above its melting point to allow sealant incorporation, then cooling to solidify the integrated structure, the manufacturing process achieves integration without excessive complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The patch effectively adheres to tissues while sealing leaks, demonstrating strong adhesion and biodegradability, suitable for various applications including wound closure and fluid leakage, with enhanced adhesion half-life and targeted drug release options.
Implementation Method 1
the fibrinogen acts to attach the polymer film to the tissue
Implementation Method 2
a biocompatible polymer film into which a fibrin-based sealant is incorporated
Data Source
Figure 1A~1B
Figure 2A~2C
Figure 3A~3C
AI summary
A novel fibrinogen-based tissue adhesive patch is disclosed. The patch comprises a backing made from a non-permeable biocompatible polymer film into which a fibrinogen-based sealant is incorporated. In preferred embodiments of the invention, the fibrinogen-based sealant comprises fibrinogen, thrombin, and CaCl2. The polymer backing serves to seal the tissue to which the patch is applied, and the sealant acts only to bind the patch to the affected tissue. The patch does not include any mesh or woven component. Methods of production of the patch are also disclosed.