Implantable Fibrosis Cage Dialysis Device for Continuous Kidney Function
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Solution Overview
Problem
Current dialysis methods for treating chronic kidney disease are invasive, uncomfortable, and prone to infection, with traditional extracorporeal processing not emulating continuous kidney function, leading to discomfort, inconvenience, and high mortality rates among patients.
Innovation Solution
A partially or fully implantable medical device with a partially porous mesh forming a fibrosis cage, incorporating a dialysis chamber and pumping means for fluid removal, and optionally an electrodialyzer, designed for intra-corporeal dialysis to facilitate continuous and frequent treatment with reduced discomfort and infection risk.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional extracorporeal dialysis is used, then waste components can be removed from blood, but the treatment is intermittent and does not emulate continuous kidney function
Solution Approach 1:
The device places a dialysis chamber inside a fibrosis-forming mesh cage, creating a nested structure where the inner chamber performs dialysis while the outer cage creates an acellular space. This nested design enables continuous intracorporeal dialysis by maintaining constant contact between dialysate and peritoneal fluid, emulating continuous kidney function without intermittent treatment cycles.
Solution Approach 2:
The invention introduces a fibrosis-forming mesh cage as an intermediary structure that creates an acellular space between the dialysis chamber and surrounding tissues. This intermediary layer prevents cell infiltration while allowing fluid exchange, enabling continuous dialysis operation without the interruptions required by traditional extracorporeal methods.
2Reliability
If frequent and prolonged dialysis sessions are implemented, then patient survivability improves, but discomfort and inconvenience increase
Solution Approach 1:
The device enables self-contained intracorporeal dialysis where the dialysis chamber is implanted within the patient's body and continuously performs fluid exchange without requiring external equipment or frequent patient visits. The fibrosis cage maintains the acellular space automatically, allowing the system to serve itself continuously, improving survivability while eliminating the discomfort of frequent extracorporeal sessions.
3Reliability
If dialysis frequency and duration are increased, then waste removal effectiveness improves, but treatment costs and procedural complexity increase
Solution Approach 1:
The invention merges the dialysis chamber with the fibrosis-forming mesh cage into a single integrated implantable device. This combination eliminates the need for separate extracorporeal equipment and complex procedural setups, allowing continuous waste removal effectiveness while reducing overall procedural complexity and treatment costs compared to frequent traditional dialysis sessions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device enables continuous and frequent fluid removal with reduced discomfort and infection risk, improving patient quality of life and survival rates by mimicking continuous kidney function and minimizing invasive procedures.
Implementation Method 1
a partially porous mesh that forms a fibrosis cage upon implantation into a patient
Implementation Method 2
Dialysis emulates kidney function by removing waste components and excess fluid from a patient's blood. This is accomplished by allowing the body fluids, usually the blood, to come into the close proximity with the dialysate, which is a fluid that serves to cleanse the blood and actively remove the waste components and excess water. During this process, the blood and dialysate are separated by a dialysis membrane, which is permeable to water, small molecules (such as urea), and ions but not permeable to the cells.
Implementation Method 3
a pumping means for pumping fluid out of the fibrosis cage
Data Source
AI summary
The invention relates to a method and device for dialysis and or bulk fluid removal by generating a fibrosis chamber within a body cavity and performing dialysis or bulk fluid removal. An implantable medical device is described having a fibrosis chamber and a pump. A dialysis chamber and an optional electrodialysis unit can further be provided. An additional controller uses sensory feedback to regulate the fluid levels by altering the extracellular fluid retention within the fibrosis chamber. This device can be used for the treatment of patients with chronic kidney disease who may also be suffering from cardiorenal syndrome and hypertension.