Computer-Aided Liver Fibrosis Scoring via Image Segmentation

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Solution Overview

Problem

Conventional methods for diagnosing liver fibrosis rely on subjective doctor judgment, lacking an objective scoring system to accurately assess the degree of fibrosis and guide appropriate treatment.

Innovation Solution

A computer-aided method using a processor and memory to analyze medical images by performing segmentation algorithms, detecting circular fibrosis, calculating scores based on fibrosis size and shape, and evaluating fibrosis bridges between portal areas and central veins, providing an objective fibrosis scoring system.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional subjective judgment methods are used for fibrosis scoring, then the process is simple and quick, but the scoring lacks objectivity and accuracy

Engineering Contradiction:
Improvescoring accuracyVSAvoidsystem complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent replaces the mechanical system of subjective human judgment with an automated image processing system that uses segmentation algorithms, morphological operations, and quantitative analysis to objectively measure fibrosis characteristics, thereby eliminating human bias while maintaining operational simplicity through computer automation

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent transforms the subjective scoring process into an objective measurement by changing the parameters from qualitative doctor assessment to quantitative image analysis metrics, including area ratios, circularity measurements, and fibrosis bridge detection, which provide precise and reproducible scoring

Inventive Principle:
Principle #35Parameter changes

2Reliability

If automated image analysis is implemented for fibrosis scoring, then objectivity and accuracy are improved, but the computational complexity and processing time increase

Engineering Contradiction:
Improvescoring objectivityVSAvoidprocessing time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The patent applies segmentation to divide the complex fibrosis assessment into distinct analytical components: segmentation of fibrosis regions from normal tissue, identification of portal areas and central veins, detection of fibrosis bridges, and calculation of circular fibrosis metrics. This modular approach enables parallel processing and reduces overall computation time while maintaining comprehensive analysis

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent implements optimized image processing that performs necessary analysis on key regions of interest rather than processing the entire image uniformly. By focusing computational resources on detecting fibrosis bridges between portal areas and central veins, and calculating area ratios only where fibrosis is present, the system achieves reliable scoring with reduced processing time

Inventive Principle:
Principle #16Partial or excessive action

Data Source

PatentUS11508060B2Computer aided method and electrical device for analyzing fibrosis
Publication Date: 2022.11.22 NAT CHENG KUNG UNIV
  • US11508060B2 patent drawing
  • US11508060B2 patent drawing
  • US11508060B2 patent drawing

AI summary

A computer aided method for analyzing fibrosis is provided. First, a segmentation algorithm is performed on a medical image to obtain a segmentation image. Circular fibrosis is detected according to the segmentation image to determine a score. In some cases, it is also necessary to determine a number of fibrosis bridges and the condition of fiber expansion.