Film Scrap Reduction via Parameter Correlation

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Solution Overview

Problem

Current film dosage manufacturing processes result in significant scrap material, particularly when producing self-supporting films, leading to inefficiencies and increased costs due to the waste of expensive active pharmaceutical ingredients.

Innovation Solution

A method and system that utilize a computer-based system to determine and adjust processing parameters, such as mixer settings and coating widths, to minimize scrap production during the manufacturing of self-supporting films, optimizing yield and reducing waste by correlating scrap factors with processing parameters.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Loss of substance

If current manufacturing processes are used to produce self-supporting film dosages, then individual doses can be formed, but significant scrap material is generated leading to material waste and increased costs

Engineering Contradiction:
Improvescrap materialVSAvoidmanufacturing efficiency
Core Design Contradiction:
Loss of substanceVSProductivity

Solution Approach 1:

The system implements a feedback mechanism where scrap factors are determined from processing data, correlated with processing parameters, and used to adjust those parameters in real-time or between runs. This closed-loop control continuously optimizes the manufacturing process to minimize scrap generation while maintaining productivity.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The invention systematically varies processing parameters (such as coating width, mixer settings, drying conditions) to identify optimal settings that minimize scrap. By correlating scrap factors with specific parameters and adjusting them, the process transforms from a fixed procedure to an optimized, adaptive manufacturing system.

Inventive Principle:
Principle #35Parameter changes

2Loss of substance

If processing parameters are adjusted to reduce scrap, then material yield improves, but process complexity increases due to data compilation and parameter correlation requirements

Engineering Contradiction:
Improvematerial wasteVSAvoidsystem complexity
Core Design Contradiction:
Loss of substanceVSDevice complexity

Solution Approach 1:

The processor performs multiple functions: compiling production data, determining scrap factors, correlating with processing parameters, and adjusting parameters. This multi-functional system consolidates what could be separate complex subsystems into a single integrated unit, reducing overall system complexity while achieving scrap minimization.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The system uses its own processing data to automatically determine scrap factors and adjust parameters without external intervention. The manufacturing system serves itself by using embedded sensors and processors to monitor and optimize its own operation, reducing the need for external complex control systems.

Inventive Principle:
Principle #25Self-service

Data Source

PatentEP2533769B1Method and system for optimizing film production and minimizing film scrap
Publication Date: 2019.04.10 AQUESTIVE THERAPEUTICS INC
  • EP2533769B1 patent drawingFigure 1
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AI summary

The present invention relates to a method of optimizing self-supporting film production which includes the steps of: determining at least one scrap factor which relates to a total amount of scrap in processing a film product; correlating the at least one scrap factor to at least one processing parameter; and adjusting the at least one processing parameter to reduce the total amount of scrap in processing the film product.