Filter Integrity Testing With Adaptive Flow Check Timing

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Existing filter integrity tests are inefficient and lack dependability, particularly in terms of time and accuracy, especially when using non-destructive methods like the diffusion test and water flow test.

Innovation Solution

A method that adaptively determines the duration of the integrity test based on the reliability of the flow rate measurements, using variable check durations and multiple stop criteria to ensure accurate and efficient assessment of filter integrity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If a fixed stabilization time and check duration are used in non-destructive integrity tests, then the test procedure is simple to implement, but the test efficiency is reduced due to unnecessarily long test times when filters pass early

Engineering Contradiction:
Improvetest efficiencyVSAvoidtest time
Core Design Contradiction:
ProductivityVSLoss of time

Solution Approach 1:

The patent applies dynamics by transitioning from fixed, static test durations to adaptive, dynamic timing. The check phase duration is no longer predetermined but adjusts in real-time based on flow rate measurements. The system dynamically determines when to terminate the check phase by evaluating whether the measured flow rate has stabilized below the threshold, allowing the test to end as soon as sufficient evidence of filter integrity is obtained, thereby eliminating unnecessary waiting time while maintaining reliability.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The patent implements feedback by continuously monitoring the flow rate during the check phase and using this information to control the test duration. The system measures the flow rate at multiple time points, compares it against the threshold, and adjusts the check phase termination accordingly. This closed-loop feedback mechanism allows the test to adapt to actual filter performance, ending the test early when the flow rate clearly indicates integrity, thus improving efficiency without sacrificing dependability.

Inventive Principle:
Principle #23Feedback

2Reliability

If the check phase duration is extended to ensure reliable flow rate measurements, then the dependability of the test improves, but the test time increases reducing overall efficiency

Engineering Contradiction:
Improvedependability of testVSAvoidtest time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The patent applies partial action by performing just enough measurements to achieve the required reliability threshold. Rather than using a fixed excessive duration that guarantees reliability in all cases, the system performs the minimum necessary check phase duration adaptively determined by actual measurements. When the flow rate stabilizes well below the threshold, the system stops checking, having obtained sufficient evidence for reliable determination, thus avoiding unnecessary extension of test time while maintaining dependability.

Inventive Principle:
Principle #16Partial or excessive action

Solution Approach 2:

The patent uses preliminary action by conducting a stabilization phase before the check phase to prepare the system for accurate measurements. During stabilization, the test pressure is applied and the system reaches equilibrium, ensuring that subsequent flow rate measurements during the check phase are reliable from the outset. This preliminary preparation reduces the duration needed during the actual check phase to achieve dependable results, as measurements start from a stable baseline rather than requiring extended observation to establish stability.

Inventive Principle:
Principle #10Preliminary action

3Measurement precision

If multiple flow rate measurements are taken during the check phase to ensure accuracy, then the measurement precision improves, but the complexity of the test procedure increases

Engineering Contradiction:
Improveflow rate measurement accuracyVSAvoidtest procedure complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent applies self-service by implementing automated measurement and evaluation procedures that require minimal human intervention. The system automatically takes multiple flow rate measurements during the check phase, compares them against the threshold, determines when stability is achieved, and terminates the test accordingly. This automation handles the complexity of multiple measurements internally, maintaining high measurement precision while keeping the operational complexity low for the user, as the system manages the measurement sequence and decision-making autonomously.

Inventive Principle:
Principle #25Self-service

4Adaptability or versatility

If a fixed test procedure with predetermined durations is used, then the ease of operation is high, but the adaptability to different filter performance scenarios is reduced

Engineering Contradiction:
Improveadaptability to filter performanceVSAvoidoperational simplicity
Core Design Contradiction:
Adaptability or versatilityVSEase of operation

Solution Approach 1:

The patent applies dynamics by making the test procedure adaptive rather than static. The check phase duration automatically adjusts based on actual filter performance during testing. For filters that quickly demonstrate integrity, the check phase terminates early; for filters requiring longer observation, the check phase extends accordingly. This dynamic adaptation maintains ease of operation because the system autonomously manages the variable timing, presenting a simple interface to the user while internally adapting to different filter scenarios.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The patent uses parameter changes by allowing the check phase duration parameter to vary based on measured flow rate characteristics. Rather than fixing this parameter beforehand, the system modifies it in real-time based on whether the flow rate stabilizes quickly or requires longer observation. This parameter adaptation enhances versatility across different filter types and performance scenarios while maintaining operational simplicity, as the parameter adjustment is automated and transparent to the operator.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enhances the efficiency and dependability of filter integrity testing by ensuring reliable flow rate measurements, reducing test time while maintaining accuracy and quality.

Implementation Method 1

pressurizing an upstream side of the filter to a test pressure

Methodology Applied
Scientific EffectPressure gradient: Pressure Gradient

Implementation Method 2

a sterile membrane filter comprising a housing and a membrane inside the housing, the membrane having a given pore size

Methodology Applied
Scientific EffectPhysical filtration: Filter (physical)

Implementation Method 3

In the diffusion test, the physical quantity is the diffusion of a gas through a wetted filter

Methodology Applied
Scientific EffectDiffusion: Diffusion

Implementation Method 4

in the water flow test the physical quantity is the flow of water through a hydrophobic filter

Methodology Applied
Scientific EffectBulk flow:

Data Source

PatentUS12584843B2Method and system for testing the integrity of filters
Publication Date: 2026.03.24 SARTORIUS STEDIM BIOTECH GMBH
  • US12584843B2 patent drawing
  • US12584843B2 patent drawing
  • US12584843B2 patent drawing

AI summary

A method for testing integrity of a filter can include pressurizing an upstream side of the filter to a test pressure and performing a check step that includes determining a flow rate of fluid from the upstream side to a downstream side of the filter, comparing the determined flow rate with a flow range including a flow threshold, and setting stop criteria based on the comparison.