Fine-Particle Crosslinked PVP Tablet Disintegrant
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Solution Overview
Problem
Coarse crosslinked polyvinylpyrrolidone disintegrants in tablets lead to a rough surface, low resistance to crushing, inhomogeneous mixing, segregation, and an unpleasant mouthfeel, while smaller particle sizes result in reduced disintegrant effect and increased moisture sensitivity.
Innovation Solution
Fine-particle crosslinked polyvinylpyrrolidone with an average particle size of 5-60 μm and hydration capacity greater than 7 g/g, prepared through popcorn polymerization, which can be controlled by inert gas flow and polymerization conditions, is used as a tablet disintegrant.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If coarse crosslinked polyvinylpyrrolidone (particle size >100 μm) is used as tablet disintegrant, then good disintegrant effect is achieved, but tablet surface becomes rough, resistance to crushing decreases, mixing becomes inhomogeneous, and segregation occurs
Solution Approach 1:
The patent changes the critical parameter of particle size from coarse (>100 μm) to fine (5-60 μm) while maintaining the crosslinked polyvinylpyrrolidone chemistry. This parameter change resolves the contradiction by providing both smooth tablet surfaces and adequate disintegrant effect, as the fine particles eliminate surface roughness and segregation while the crosslinked structure maintains disintegration capability.
2Manufacturing precision
If fine crosslinked polyvinylpyrrolidone (particle size 5-60 μm) is used as tablet disintegrant, then smooth tablet surface and homogeneous mixing are achieved, but disintegrant effect is reduced and moisture sensitivity increases
Solution Approach 1:
The patent creates a composite material system combining fine particle size (5-60 μm) with crosslinked polyvinylpyrrolidone chemistry. This composite approach allows the fine particles to provide smooth surfaces and homogeneous mixing while the crosslinked structure maintains high disintegrant effect and reduces moisture sensitivity, resolving the contradiction between fine particle benefits and disintegrant performance.
3Duration of action of moving object
If higher concentration of small-particle disintegrant is used to achieve adequate disintegrant effect, then disintegration is improved, but costs increase and tablets become more moisture-sensitive
Solution Approach 1:
The patent changes the particle size parameter to fine (5-60 μm) which increases the surface area to volume ratio, thereby enhancing the disintegrant effect per unit mass. This allows achievement of adequate disintegrant effect at lower concentrations, reducing both costs and moisture sensitivity issues associated with higher concentrations of coarse particles.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The fine-particle disintegrants provide a smooth tablet surface, high resistance to crushing, homogeneous mixing, and a pleasant mouthfeel, maintaining disintegrant effect even under moist conditions, suitable for fast-disintegrating tablets and wet granulation processes.
Implementation Method 1
crosslinked polyvinylpyrrolidone with an average particle size of from 5 to 60 μm and a hydration capacity greater than 7 g/g
Data Source
AI summary
Use of crosslinked polyvinylpyrrolidone with an average particle size of 5-60 μm and a hydration capacity of greater than 7 g/g as tablet disintegrant.