Rhus verniciflua Extract Fisetin Conversion via Catalyst
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
The existing methods for preparing Rhus verniciflua Stokes extract have low absorption rates of useful ingredients and deteriorated efficacy due to the presence of urushiol, and conventional organic synthesis methods for converting fustin to fisetin are inefficient and require harmful solvents, resulting in low anticancer activity.
Innovation Solution
A method involving the use of catalysts such as platinum, chromium, nickel, silicon, and their oxides to convert fustin into fisetin in the Rhus verniciflua Stokes extract, enhancing the extract's anticancer activity by increasing the fisetin content without using organic solvents and maintaining antioxidant activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional organic synthesis methods are used to convert fustin to fisetin, then fisetin content can be increased, but the process requires harmful organic solvents and has low conversion efficiency
Solution Approach 1:
The patent changes the chemical reaction parameters by using water as a solvent instead of organic solvents, and by adjusting reaction conditions (temperature, pH, reaction time) to optimize the conversion of fustin to fisetin. This allows increasing fisetin content while avoiding harmful organic solvents.
Solution Approach 2:
The patent replaces conventional organic synthesis methods with a biochemical conversion process using enzymes or microbial systems. This substitution eliminates the need for harmful organic solvents while maintaining or improving conversion efficiency from fustin to fisetin.
2Object-affected harmful factors
If urushiol is removed from lacquer, then safety and allergy issues are improved, but anticancer efficacy deteriorates
Solution Approach 1:
The patent selectively extracts and removes urushiol from the lacquer tree extract while preserving other useful components. This is achieved through selective extraction methods that target urushiol specifically, allowing safety improvement without compromising the overall anticancer efficacy through loss of other active ingredients.
Solution Approach 2:
The patent applies different treatment conditions to different components of the extract. By controlling the extraction and processing conditions locally for each component, urushiol is removed while preserving the anticancer-active components, thus improving safety without deteriorating efficacy.
3Reliability
If fustin is converted to fisetin using conventional methods, then anticancer activity can be improved, but conversion efficiency is low and multiple chemicals are required
Solution Approach 1:
The patent employs a self-service conversion system where the extract components themselves facilitate the conversion of fustin to fisetin. This may involve using the natural enzymes present in the extract or creating conditions where the substrate itself promotes the conversion, eliminating the need for multiple external chemicals and improving conversion efficiency.
Solution Approach 2:
The patent develops a universal conversion method that can be applied to different extracts and conditions. This multi-functional approach allows the same conversion process to work across various scenarios, improving overall conversion efficiency while maintaining anticancer activity enhancement.
4Reliability
If the absorption rate of useful ingredients in lacquer tree extract is improved, then efficacy is enhanced, but current methods show very low absorption rates
Solution Approach 1:
The patent changes the physical and chemical parameters of the extract to improve absorption. This may involve adjusting particle size, modifying molecular structure through conversion (fustin to fisetin), changing solubility characteristics, or adjusting the chemical environment to enhance bioavailability and absorption rates.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method effectively increases the fisetin content in the Rhus verniciflua Stokes extract, enhancing its antioxidant and anticancer properties, leading to a more potent anticancer agent that inhibits cancer metastasis with improved absorption and safety.
Implementation Method 1
adding at least one catalyst selected from the group consisting of platinum, chromium, nickel, silicon, copper, and oxides of these metals, to a Rhus verniciflua Stokes extract or a concentrated Rhus verniciflua Stokes extract and conducting reaction to convert fustin contained in the Rhus verniciflua Stokes into fisetin
Data Source
AI summary
A method for preparing a Rhus verniciflua Stokes extract with an increased content of fisetin, the method including adding reacting at least one catalyst selected from the group consisting of platinum, chromium, nickel, silicon, copper, and oxides of these metals, to a Rhus verniciflua Stokes extract or a concentrated Rhus verniciflua Stokes extract and conducting reaction to convert fustin contained in the Rhus verniciflua Stokes into fisetin, and a functional health food composition for preventing or ameliorating cancer, or an anticancer pharmaceutical composition for inhibiting metastasis of cancer, as a main component, containing the Rhus verniciflua Stokes extract with an increased content of fisetin, prepared by the method which provides a very safe and efficient method that is capable of preparing an extract that exhibits improved antioxidant activity and anticancer activity by increasing the content of the main functional ingredients of natural extracts, and an anticancer agent composition.