Fish Brain Extract Appetite Suppression Without CNS Side Effects
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Solution Overview
Problem
Current methods for regulating food intake, particularly for obesity prevention and treatment, often come with side effects or are difficult to implement due to direct central nervous system effects and addiction risks, and there is a need for safer and more accessible approaches.
Innovation Solution
A food intake regulator using a highly concentrated fish brain as an active ingredient, which can be administered orally or in various forms, including pharmaceuticals and foods, to suppress appetite and regulate food intake without side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If mazindol is used to suppress food intake, then food intake regulation is achieved, but side effects and addiction risks occur
Solution Approach 1:
The patent uses fish brain extract as an intermediary substance that regulates food intake through natural neurochemical mechanisms rather than direct central nervous system stimulation. The fish brain contains endogenous peptides and neurotransmitters that modulate appetite regulation pathways, providing a safer alternative to mazindol while maintaining effective food intake suppression.
Solution Approach 2:
The patent employs a natural, biodegradable substance (fish brain extract) that can be safely eliminated from the body without accumulation or long-term dependency. This contrasts with mazindol, which requires careful management of dependency and withdrawal. The fish brain extract serves as a temporary, non-addictive intervention that resolves the immediate food intake regulation need without creating long-term harmful effects.
2Reliability
If precursors of serotonin, dopamine, norepinephrine and histamine are used to suppress food intake, then food intake regulation is achieved, but the complexity of the substance composition increases
Solution Approach 1:
The patent combines multiple food intake-regulating components present in fish brain into a single integrated extract. Rather than using separate synthetic precursors of serotonin, dopamine, norepinephrine, and histamine, the fish brain extract naturally contains a synergistic mixture of these neurochemicals and their regulators, simplifying the overall composition while maintaining comprehensive appetite suppression effects.
Solution Approach 2:
The patent utilizes a composite biological material (fish brain extract) that inherently contains multiple active components working together. This composite approach replaces the need for separate synthetic neurotransmitter precursors, providing a more unified and less complex substance that achieves the same food intake regulation through natural synergistic interactions.
3Object-affected harmful factors
If fruit body of pleurotus ostreatus or avocado are used to suppress food intake, then safer approach is achieved, but the effectiveness and concentration of food intake suppression is reduced
Solution Approach 1:
The patent changes the source parameter from plant-based materials (pleurotus ostreatus, avocado) to animal-based material (fish brain). This parameter change enables access to more potent neurochemical regulators of appetite, including endogenous peptides and neurotransmitters that directly target hunger centers in the brain, thereby achieving stronger and more reliable food intake suppression while maintaining safety.
Solution Approach 2:
The patent copies the natural appetite-regulating mechanisms of the fish brain, which have evolved to control food intake in aquatic organisms. By extracting and utilizing these same neurochemical pathways, the patent achieves effective food intake suppression that mirrors the natural regulatory function, providing both safety and effectiveness simultaneously.
Data Source
AI summary
A safe and widely-applicable food intake regulator can be provided by using at least one of a fish brain and parts thereof, which have the activity to regulate suppress food intake.