Fish Skin Decellularized Scaffold for Tissue Regeneration

Solution Overview

Problem

Current scaffold materials for wound care and tissue healing, such as those derived from human, animal, or synthetic sources, face challenges in handling and effectiveness due to their form and composition, with a need for improved products and methods to enhance wound healing and tissue repair.

Innovation Solution

A decellularized extracellular matrix scaffold material is developed from fish skin, maintaining its native three-dimensional structure and composition, which supports cell migration, adherence, proliferation, and differentiation, and is processed to be biocompatible and easily handled.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If scaffold materials are derived from human, animal, or synthetic sources, then tissue regeneration capability is improved, but handling difficulty increases and composition complexity worsens

Engineering Contradiction:

Improvetissue regeneration capabilityVSAvoidhandling ease

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent changes the physical state parameter of the scaffold material by freeze-drying it, transforming it from a gel-like state to a stable, handleable solid state. This parameter change enables easy handling and storage while preserving the decellularized ECM's tissue regeneration capability.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent extracts and removes cellular components from the fish skin ECM through decellularization processes, eliminating the harmful factor of cell presence while retaining the beneficial extracellular matrix structure for tissue regeneration.

Inventive Principle:

Principle #2Taking out (Extraction)

2Reliability

If scaffold materials are derived from human, animal, or synthetic sources, then tissue regeneration capability is improved, but product complexity increases

Engineering Contradiction:

Improvetissue regeneration capabilityVSAvoidcomposition complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent extracts and removes cellular components from the fish skin ECM through decellularization processes, eliminating the harmful factor of cell presence while retaining the beneficial extracellular matrix structure for tissue regeneration.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent changes the physical state parameter of the scaffold material by freeze-drying it, transforming it from a gel-like state to a stable, handleable solid state. This parameter change enables easy handling and storage while preserving the decellularized ECM's tissue regeneration capability.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If fish skin is processed into gel form or solution, then scaffold functionality is maintained, but ease of handling deteriorates

Engineering Contradiction:

Improvescaffold functionalityVSAvoidease of handling

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent utilizes phase transition through freeze-drying, transforming the fish skin ECM from a gel-like state to a stable, handleable solid state. This phase change maintains the scaffold's functional three-dimensional structure while dramatically improving ease of handling and storage.

Inventive Principle:

Principle #36Phase transitions

Data Source

PatentEP2485779B8A scaffold material for wound care and/or other tissue healing applications

Publication Date: 2018.04.04 KERECIS EHF

AI summary

A scaffold material for wound care and/or other tissue healing applications and methods for making the same is described. The scaffold material is constituted of a decellularized extracellular matrix from fish skin. The scaffold material may also include lipids from the lipid layer of the fish skin. Methods for making and using the scaffold material are also described.