Five-Layer Microfluidic Chip for Blood Coagulation Detection
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Solution Overview
Problem
Current microfluidic blood coagulation detection chips face challenges with large size, high production costs, and interference between electrodes, which affect detection accuracy and efficiency.
Innovation Solution
A five-layer microfluidic blood coagulation detection chip design featuring a closed microfluidic channel and multiple independent detection chambers, with electrodes placed within each chamber to minimize interference, and a specific structural form for the main and branching microfluidic channels to facilitate sample injection and reduce flow resistance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If multiple detection chambers share a common reference electrode and working electrode on the bottom layer, then device complexity is reduced, but electrode interference increases and detection accuracy deteriorates
Solution Approach 1:
The patent divides the electrode system into five separate layers, with each layer containing its own reference electrode and working electrode. This segmentation eliminates electrode interference between channels while maintaining multi-channel detection capability, resolving the contradiction between device complexity and measurement precision.
Solution Approach 2:
The patent transitions from a planar electrode arrangement (2D) to a three-dimensional layered structure (3D). By stacking five layers vertically, each with dedicated electrodes, the system achieves independent electrochemical detection in multiple channels without electrode interference, improving detection accuracy while managing complexity through vertical integration.
2Ease of manufacture
If a three-layer chip structure is used, then manufacturing simplicity is improved, but chip size becomes too large and detection efficiency is reduced
Solution Approach 1:
The patent employs a five-layer stacked configuration that utilizes the vertical dimension to increase the number of detection chambers. This approach packs more detection channels into a compact footprint, improving detection efficiency and reducing overall chip size compared to planar expansions, while maintaining relatively simple manufacturing through layer stacking.
Solution Approach 2:
The patent implements a nested layered structure where five functional layers are stacked and integrated vertically. Each layer contains specific components (electrodes, channels, chambers) that are nested within the overall chip architecture, allowing high-density integration of multiple detection channels in a compact form factor.
3Volume of moving object
If electrode spacing is reduced to decrease chip size, then chip compactness is improved, but electrode interference increases and detection accuracy deteriorates
Solution Approach 1:
By arranging electrodes in separate vertical layers rather than spacing them closely in the same plane, the patent reduces lateral electrode interference while maintaining compact chip dimensions. The vertical separation in the z-dimension allows closer horizontal integration without sacrificing detection accuracy.
Solution Approach 2:
The patent segments the electrode system into five independent layers, with each layer's electrodes spatially isolated from others. This segmentation prevents electrical interference between channels while allowing the chip to maintain a compact overall size through efficient vertical stacking.
4Quantity of substance
If microfluidic channels are designed with complex branching structures to reduce flow resistance, then fluid flow is improved, but device complexity increases and manufacturing difficulty rises
Solution Approach 1:
The patent utilizes vertical layering to create three-dimensional microfluidic pathways that reduce flow resistance. By routing channels across multiple layers with vertical connections, the design achieves efficient fluid distribution to multiple chambers without requiring overly complex planar branching, balancing flow performance with manufacturability.
Data Source
AI summary
A multi-channel microfluidic blood coagulation detection chip having a five-layer structure includes a chip body. The chip body includes, in sequence from top to bottom, a first-layer chip, a second-layer chip, a third-layer chip, a fourth-layer chip, and a fifth-layer chip. The first-layer chip (1), the second-layer chip, the third-layer chip, the fourth-layer chip, and the fifth-layer chip cooperate with each other to define a closed microfluidic channel and a plurality of mutually-independent detection chambers. The first-layer chip is provided with a sample loading hole, and the sample loading hole communicates with the detection chambers through the microfluidic channel. The chip body further includes electrodes, and the electrodes are disposed within the detection chambers in one-to-one correspondence.