Apheresis Platelets Fixed Residual Plasma Volume
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Solution Overview
Problem
Current methods for collecting and storing platelets often result in residual plasma, which is not ideal for extended storage due to its valuable nature and potential for allergic reactions, and require adjusting the plasma to synthetic additive solution ratio based on platelet yield, complicating the storage environment.
Innovation Solution
A system and method that utilize a fixed volume of residual plasma in combination with a variable amount of synthetic additive solution to create a consistent storage medium for platelets, independent of platelet yield, ensuring effective storage for up to 9 days by determining the required volume based on the targeted number of platelets.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If plasma is removed from platelet concentrate during apheresis, then the risk of allergic reactions is reduced and storage stability is improved, but the platelet concentrate requires adjustment of plasma to synthetic additive solution ratio based on platelet yield
Solution Approach 1:
The system pre-determines a fixed residual plasma volume (e.g., 30 ml) to remain with the platelet concentrate before adding synthetic additive solution. This preliminary decision eliminates the need for post-collection ratio adjustments and simplifies the storage process while ensuring consistent platelet viability.
Solution Approach 2:
The invention changes the parameter of residual plasma volume from a variable amount (based on platelet yield) to a fixed predetermined volume. This parameter change simplifies the storage medium composition and eliminates the complexity of adjusting plasma-to-additive-solution ratios.
2Ease of operation
If a fixed volume of residual plasma is used in platelet storage, then the storage process is simplified and platelet viability is maintained, but the total volume of storage medium must be carefully controlled
Solution Approach 1:
The system incorporates feedback mechanisms to monitor and control the volume of residual plasma remaining with the platelet concentrate. Sensors and control algorithms ensure that the predetermined volume (e.g., 30 ml) is achieved accurately, maintaining both simplicity and precision.
Solution Approach 2:
The apheresis system automatically controls the plasma removal process to achieve the desired fixed residual plasma volume without requiring manual intervention. The system self-regulates the plasma-to-additive-solution ratio based on pre-programmed parameters.
3Object-affected harmful factors
If most plasma is removed during apheresis to reduce allergic reactions, then storage safety is improved, but platelet metabolism and function may be affected
Solution Approach 1:
The invention optimizes the residual plasma volume parameter to a specific fixed amount (e.g., 30 ml) that balances two competing requirements: reducing allergic reaction risk by removing most plasma while maintaining sufficient plasma to support platelet metabolism and function during storage.
Solution Approach 2:
The storage medium becomes a composite system combining a fixed small volume of residual plasma with synthetic additive solution. This composite approach leverages the beneficial properties of both plasma (metabolic support) and synthetic solution (safe, controllable environment).
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for the extended storage of platelets with minimal residual plasma, reducing the risk of allergic reactions and maintaining platelet viability and functionality, while eliminating the need for pre-determined ratios, thus providing a stable storage environment regardless of platelet count.
Implementation Method 1
platelets are separated from whole blood and concentrated in the centrifuge chamber or elsewhere in the fluid processing set
Data Source
AI summary
Methods and systems for obtaining platelets are disclosed. Platelets are collected in a pre-determined volume of plasma and a determined amount of a combined storage medium including the pre-determined amount of plasma and a volume of a synthetic additive solution.