Flavanone Bone Remodeling Accelerator for Osteoporosis

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Solution Overview

Problem

Current treatments for osteoporosis often suppress bone resorption but also inhibit bone formation, and there is a need for a safe agent that can promote bone formation and prevent or improve osteoporosis effectively for long-term use.

Innovation Solution

A bone remodeling accelerator comprising flavanone and its glycoside, specifically 3′,4′,7-trihydroxyflavanone and its glycoside, extracted from the Chamaecrista genus, which promotes bone resorption and formation in balance, suitable for pharmaceutical or food compositions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If bisphosphonate preparations are used to suppress bone resorption, then bone mass increases, but bone formation is also suppressed

Engineering Contradiction:

Improvebone massVSAvoidbone formation

Core Design Contradiction:

Quantity of substanceVSProductivity

Solution Approach 1:

The patent extracts and isolates specific active components (flavanone and its glycoside) from the Chamaecrista plant to create a targeted treatment that selectively promotes bone formation without the side effects of conventional drugs. This extraction principle allows the active ingredients to specifically stimulate osteoblast function while avoiding suppression of bone formation.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The flavanone and its glycoside act as intermediary substances that mediate between the plant source and bone tissue. These intermediaries specifically target osteoblast cells to enhance bone formation activity without interfering with the normal bone resorption-formation balance, thus resolving the contradiction between increasing bone mass and maintaining bone formation.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Quantity of substance

If hormone preparations such as parathyroid hormone are used to promote bone formation, then bone mass increases, but hormone-like actions occur

Engineering Contradiction:

Improvebone massVSAvoidhormone-like action

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent uses plant-derived flavanone and its glycoside as temporary, non-hormonal agents that stimulate bone formation through a different mechanism than hormone preparations. These short-acting plant compounds promote osteoblast activity without causing the systemic hormone-like effects associated with parathyroid hormone preparations, providing a safer alternative for long-term use.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Reliability

If conventional osteoporosis treatments are used, then bone resorption is suppressed, but safety for long-term continuous administration is limited

Engineering Contradiction:

Improvebone resorption suppressionVSAvoidsafety

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the fundamental parameter of treatment from synthetic hormone-based or drug-based approaches to plant-derived natural compounds. By using flavanone and its glycoside from Chamaecrista, the treatment achieves bone resorption suppression and bone formation promotion through natural biochemical pathways that are safer for long-term continuous administration without the harmful side effects of conventional medications.

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS11517603B2Bone remodeling accelerator

Publication Date: 2022.12.06 HOKURIKU UNIVERSITY

AI summary

The present invention provides a preventing or improving agent that can favorably promote bone formation, is effective in preventing or improving osteoporosis or a decrease in bone strength, has high safety, and is suitable for long-term continuous ingestion or administration, by forming a bone remodeling accelerator comprising one or more kinds selected from the group consisting of flavanone and a glycoside thereof.