Flexible Container Concentration Measurement via Variable Path Length

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Solution Overview

Problem

Existing methods for determining the concentration of ingredients in closed containers with flexible walls are imprecise due to unknown optical properties of the container walls, which cause interference in spectroscopic measurements, especially when the containers or ingredients scatter optical radiation, leading to errors in concentration determination.

Innovation Solution

The solution involves conducting spectroscopic measurements with different transmission path lengths through the medium, allowing for the minimization of container wall influences by varying the distance between the container walls, and using a computing unit to form a quotient of measurements at different thicknesses, which eliminates the wall's impact on the measurement results.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If spectroscopic measurements are made through flexible container walls, then concentration determination is possible, but measurement precision deteriorates due to unknown optical properties of the walls

Engineering Contradiction:
Improveconcentration determination accuracyVSAvoidoptical property characterization requirement
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent makes the transmission path length variable by mechanically adjusting the distance between container walls, allowing dynamic measurement at multiple path lengths. This dynamic adjustment enables the system to eliminate wall influence through mathematical processing without requiring separate wall characterization measurements.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The patent changes the measurement parameter (transmission path length) to multiple values, allowing the determination of concentration independent of wall properties. By measuring at different path lengths and processing the data appropriately, the wall's optical properties are eliminated from the calculation.

Inventive Principle:
Principle #35Parameter changes

2Measurement precision

If traditional transmission measurement is used, then measurement setup is simple, but measurement precision deteriorates when container walls or ingredients scatter optical radiation

Engineering Contradiction:
Improveconcentration determination accuracy in scattering conditionsVSAvoidmeasurement arrangement complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent adds the dimension of variable path length to the measurement system. By measuring absorbance at multiple path lengths and analyzing the relationship, the system can distinguish between absorption and scattering effects, enabling accurate concentration determination even in strongly scattering conditions.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

3Reliability

If calibration is performed with predetermined concentrations, then concentration determination is possible, but reliability deteriorates when measurement situation changes due to different container wall properties

Engineering Contradiction:
Improvemeasurement consistency across different containersVSAvoidcontainer wall property variation sensitivity
Core Design Contradiction:
ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent extracts the wall influence from the measurement equation by using multiple path length measurements. The wall's optical properties appear as constant factors that can be eliminated through the mathematical relationship between measurements at different path lengths, making the system adaptable to different container walls.

Inventive Principle:
Principle #2Taking out (Extraction)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach enables accurate determination of ingredient concentrations by isolating the container wall's influence, improving measurement precision and reducing errors caused by varying container properties, even when the containers have different wall structures or materials.

Implementation Method 1

spectroscopic methods can be used that use the absorption and/or scattering of the contents to determine the desired parameters

Methodology Applied
Scientific EffectAbsorption spectroscopy: Absorption Spectroscopy

Implementation Method 2

which, based on the length of the x-ray path, knowledge of the entrance intensity and the molecular extinction of the ingredient, can determine its concentration from the measurement of the exit intensity (Lambert-Beer law)

Methodology Applied
Scientific EffectLambert-Beer law:

Implementation Method 3

Another problem arises when the containers or the ingredients scatter optical radiation

Methodology Applied
Scientific EffectScattering: Scattering

Data Source

PatentEP3017292B1Device and method for determining the concentration of a substance in a flexible container
Publication Date: 2023.09.06 MACO PHARMA SA
  • EP3017292B1 patent drawingFigure 1
  • EP3017292B1 patent drawingFigure 1
  • EP3017292B1 patent drawing

AI summary

The invention relates to a non-destructive and non-invasive method for determining the concentration or other parameters of constituent substances in fluids, which method is capable of minimizing the optical interfering influences, which are unknown but constant during the individual measurement, of the vessel wall on the measurement result or the evaluation, in that measurements are carried out with different through-radiation path lengths and quotient calculations eliminate the influences of the vessel wall. Wide-area illumination and detection ensure that non-linearities occurring during said measurements do not interfere with the accuracies of the determination.