Flexible Hemostatic Patch for Minimally Invasive Delivery
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Solution Overview
Problem
Current hemostatic agents used in open surgeries are ineffective for minimally invasive procedures due to stiffness, difficulty in navigation, and insufficient effectiveness for moderate to severe bleeding, necessitating a flexible and user-friendly solution for controlling bleeding during minimally invasive surgical procedures.
Innovation Solution
A biocompatible, flexible hemostatic patch comprising a fibrous carrier structure with reactive electrophilic and nucleophilic polymers that can be delivered through a trocar, reacting with tissue and blood to achieve hemostasis within three minutes, featuring a water-resistant cohesive fibrous carrier structure with reactive polymer particles that form covalent bonds to induce hemostasis and tissue adhesion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional hemostatic agents are used for open surgeries, then hemostasis can be achieved, but they are too stiff and damaged during introduction through trocar in minimally invasive procedures
Solution Approach 1:
The patent applies this principle by designing a flexible hemostatic patch with a thin-film structure that can be easily introduced through a trocar while maintaining its hemostatic effectiveness. The flexible nature of the patch allows it to navigate through the trocar without damage, resolving the contradiction between reliability and ease of operation.
Solution Approach 2:
The patent changes the physical parameters of the hemostatic agent by transitioning from stiff conventional materials to a flexible, compliant material that can deform during insertion through the trocar. This parameter change enables the material to maintain structural integrity during delivery while remaining effective for hemostasis.
2Reliability
If conventional hemostatic agents are used, then some hemostatic effect is achieved, but they are difficult to navigate and position at the bleeding site during robotic surgical techniques
Solution Approach 1:
The flexible thin-film design allows the hemostatic patch to be easily manipulated and positioned at the bleeding site during robotic surgery. Its flexibility enables it to conform to irregular tissue surfaces and be precisely positioned, improving both navigability and positioning accuracy while maintaining hemostatic reliability.
Solution Approach 2:
The patent incorporates dynamic properties by making the hemostatic patch flexible and adaptable, allowing it to move and conform during the surgical procedure. This dynamic characteristic enables easier navigation through the trocar and precise positioning at the bleeding site, resolving the contradiction between reliability and ease of operation.
3Ease of operation
If conventional hemostatic agents are used, then they can be applied to bleeding sites, but they are not effective enough on moderate to severe bleeding and require conversion to open surgery
Solution Approach 1:
The patent employs composite material design by combining a flexible carrier structure with reactive polymer particles that have hemostatic properties. This composite structure maintains the flexibility needed for minimally invasive delivery while incorporating materials capable of effectively controlling moderate to severe bleeding, thus resolving the contradiction between ease of operation and reliability.
Solution Approach 2:
The patent changes the functional parameters of the hemostatic material to enhance its effectiveness for moderate to severe bleeding while maintaining its flexible, minimally invasive delivery characteristics. The reactive polymer composition provides enhanced hemostatic capability without compromising the flexible nature required for trocar delivery.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hemostatic patch effectively reduces bleeding time and achieves hemostasis in minimally invasive procedures, demonstrating faster hemostatic control and reduced need for conversion to open surgery, with high efficacy in controlling moderate to severe bleeding.
Implementation Method 1
reactive electrophilic groups capable of reacting with amine groups in tissue and blood
Implementation Method 2
nucleophilic polymer carrying reactive nucleophilic groups, and an electrophilic polymer carrying at least three reactive electrophilic groups capable of reacting with the nucleophilic polymer and amine groups in tissue and blood
Data Source
AI summary
Methods and systems for using a biocompatible and flexible hemostatic sheet comprising a fibrous carrier structure, and reactive electrophilic groups capable of reacting with amine groups in tissue and blood, the hemostatic sheet delivered through a trocar for restoring hemostasis to a tissue at a bleeding site of an organ during minimally invasive treatment of hemorrhage.