Flexible Tube Assembly with Filter Tip for Controlled Gene Sample Discharge

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Solution Overview

Problem

Existing sample tubes for diagnostic kits are difficult to use due to rigid materials, large or small discharge holes, and require strong force for sample discharge, leading to inaccurate results and complex gene extraction processes.

Innovation Solution

A tube assembly with a flexible material, a filter tip having a specific discharge hole and distance ratio, and a discharge pipe design that allows controlled sample discharge as water drops, preventing evaporation and blockages, and facilitating easy sample loading and filtration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If a rigid material is used for the tube, then the tube structure is stable, but it is difficult to load the sample and requires strong force for discharge

Engineering Contradiction:
Improvetube structure stabilityVSAvoidsample loading ease
Core Design Contradiction:
Stability of the object's compositionVSEase of operation

Solution Approach 1:

The tube is made of flexible material that can be easily compressed and deformed. When the user squeezes the tube, the flexible wall allows volume reduction to discharge sample, and when released, the tube returns to its original shape, enabling easy and controlled sample loading and discharge without requiring strong force

Inventive Principle:
Principle #30Flexible shells and thin films

2Ease of operation

If the discharge hole size is too large, then the sample can be discharged easily, but the sample is dripped in the form of water streams leading to inaccurate results

Engineering Contradiction:
Improvesample discharge easeVSAvoidsample discharge precision
Core Design Contradiction:
Ease of operationVSMeasurement precision

Solution Approach 1:

The discharge hole diameter is precisely controlled within a specific range (1.377-1.683 mm) to optimize the discharge behavior. This parameter optimization ensures the sample discharges in controlled drops rather than streams, achieving both ease of discharge and measurement precision for accurate diagnostic results

Inventive Principle:
Principle #35Parameter changes

3Measurement precision

If the discharge hole size is too small, then the sample discharge is controlled, but the sample can be discharged only when strong force is applied

Engineering Contradiction:
Improvesample discharge controlVSAvoidforce required for discharge
Core Design Contradiction:
Measurement precisionVSForce

Solution Approach 1:

The flexible tube material allows the user to compress the tube volume by squeezing, which builds pressure to discharge the sample through the small discharge hole without requiring excessive force. The flexibility enables controlled pressure application, making discharge easy while maintaining precision

Inventive Principle:
Principle #30Flexible shells and thin films

4Reliability

If a complex gene extraction process is performed, then pure DNAs or RNAs can be acquired, but much time is consumed and expert manpower is necessary

Engineering Contradiction:
Improvegene extraction purityVSAvoidgene extraction time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The tube integrates multiple functions: sample storage, mixing (via vortexing), and filtration (via integrated filter). By combining these functions in one device, the complex multi-step gene extraction process is simplified, reducing both time and expertise requirements while maintaining reliability for molecular diagnosis

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enhances the precision and reliability of sample loading and gene extraction by allowing controlled, accurate sample discharge and filtration, reducing contamination and simplifying the diagnostic process.

Implementation Method 1

a filter tip 200 having a tip 210 including an insertion part 211 inserted into the hole H of the tube 100

Methodology Applied
Scientific EffectFiltration: Filter (physical)

Implementation Method 2

a discharge pipe 213 connected to the expansion part 212 and acting as a passage, through which a solution S stored in the interior of the tube 100 is discharged

Methodology Applied
Scientific EffectCapillary action: Capillary Action

Data Source

PatentUS11338282B2Tube assembly for dripping to diagnostic strip and extracting gene fragment
Publication Date: 2022.05.24 WELLS BIO
  • US11338282B2 patent drawing
  • US11338282B2 patent drawing
  • US11338282B2 patent drawing

AI summary

The present invention relates to a tube assembly for dripping. According to an embodiment, a tube assembly for dripping includes a tube (100) having a hole (H) at an upper portion thereof, and a filter tip (200) having a tip (210) including, an insertion part (211) inserted into the hole (H) of the tube (100) and, an expansion part (212) connected to the insertion part (211) and having a diameter that is larger than that of the hole (H), and a discharge pipe (213) connected to the expansion part (212) and acting as a passage, through which a solution (S) stored in the interior of the tube (100) is discharged, wherein a discharge adjusting part (213a) having a discharge hole (h) having a predetermined diameter (d1) is formed in the interior of the discharge pipe (213) that is spaced apart from a lower end of the discharge pipe (213) by a predetermined distance.