Floating Chamber System for Uniform Sample Immersion
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Solution Overview
Problem
Existing multi-well trays with rigidly attached containers face challenges in ensuring uniform liquid immersion of tissue samples due to manufacturing tolerances, leading to variations in well depth, resulting in inefficient use of reagents and potential sample exposure issues.
Innovation Solution
A floating chamber system where containers are coupled to a frame, allowing vertical translation within a limited range, ensuring full seating in wells of varying depths, and are perforated for liquid penetration, minimizing reagent usage and enabling repeated exposure to different liquids without sample transfer.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If containers are rigidly attached to the frame, then structural stability is improved, but manufacturing precision deteriorates due to variations in well depth and container depth
Solution Approach 1:
The container is designed with a floating mechanism that allows vertical movement relative to the frame. The container can move up and down within a limited range to adapt to variations in well depth, ensuring the bottom of the container always seats at the bottom of the well regardless of manufacturing tolerances.
2Reliability
If enough liquid is added to ensure full immersion of samples at any position, then reliability of sample exposure is improved, but loss of substance increases due to excessive reagent usage
Solution Approach 1:
The floating container automatically adjusts its vertical position to ensure the sample is always at the bottom of the well. This eliminates the need to add extra liquid to compensate for potential positioning variations, thereby reducing reagent consumption while maintaining reliable sample exposure.
3Device complexity
If containers are rigidly attached, then device complexity is reduced, but adaptability deteriorates due to inability to accommodate well depth variations
Solution Approach 1:
The container is designed with a floating mechanism that allows vertical movement relative to the frame. The container can move up and down within a limited range to adapt to variations in well depth, ensuring the bottom of the container always seats at the bottom of the well regardless of manufacturing tolerances.
Data Source
AI summary
A floating chamber set may include a plurality of containers coupled to a frame such that each container translates vertically within a limited vertical range independent of the other containers. Each container may be perforated to allow liquid penetration.