Floating Coupler Geometry for Robotic Connector Alignment
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Solution Overview
Problem
Conventional cell therapy manufacturing processes are labor-intensive, inefficient, and not scalable, leading to low throughput, high production costs, and significant operator variability, with closed system solutions being inflexible and underutilized.
Innovation Solution
The development of apparatuses with a floating, non-rotating design that accommodates various connectors, incorporating external lead-in features and robotic compatibility, enabling automated connections and reducing operator dependence through robotic end of arm tools (EOATs).
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If labor-based manual processes are used for cell therapy manufacturing, then operational flexibility and adaptability are maintained, but productivity and throughput remain low
Solution Approach 1:
The patent replaces manual mechanical operations with an automated robotic system that uses programmable motion control to perform cell manipulation tasks. The robotic arm with specialized end effectors automates previously manual processes including vessel handling, cell transfer, and medium exchange, thereby increasing throughput while eliminating operator variability.
Solution Approach 2:
The system incorporates self-contained automated vessels with integrated sensors and actuators that can autonomously perform functions such as self-alignment, self-latching, and self-monitoring. The robotic platform autonomously navigates and positions vessels without human intervention, enabling the system to service itself during operation.
2Manufacturing precision
If highly skilled operators are employed to ensure manufacturing precision and quality control, then product quality and reliability are maintained, but manufacturing cost and operational complexity increase
Solution Approach 1:
The system incorporates multiple sensor arrays including vision systems, force sensors, and position encoders that continuously monitor vessel positions, cell characteristics, and operational parameters. Real-time feedback loops adjust robotic motion and manipulation forces to maintain precision within specified tolerances, ensuring repeatable results without requiring skilled human operators.
Solution Approach 2:
Vessels are pre-configured with alignment features, identification markers, and standardized interfaces before being placed in the system. The robotic system performs preliminary verification of vessel integrity and compatibility through automated inspection routines, ensuring that all components are ready for precise manipulation before the manufacturing process begins.
3Productivity
If conventional separate manufacturing equipment is used placed on clean room benches, then ease of operation and accessibility are maintained, but productivity and space utilization are limited
Solution Approach 1:
The patent integrates multiple previously separate manufacturing functions into a single automated robotic platform. The system combines cell manipulation, medium exchange, waste removal, and quality monitoring functions that were previously performed by separate benchtop devices operated manually. This consolidation increases throughput while reducing the total clean room footprint by eliminating the need for multiple separate workstations.
4Loss of time
If manual batch transfer between machines is performed, then adaptability to different process requirements is maintained, but loss of time and operational efficiency increase
Solution Approach 1:
The robotic system enables continuous automated transfer of cell batches between processing vessels without manual intervention. The system maintains continuous operation by automatically preparing the next batch while the current batch is being processed, eliminating idle time between operations. Automated vessel handling and medium exchange ensure that the manufacturing process flows continuously without interruptions for manual batch transfer.
Data Source
AI summary
An apparatus includes a first coupling member for receiving a first device and a second coupling member connected to or formed with the first coupling member at a proximal end portion of the first coupling member. The second coupling member includes a revolving exterior surface having a first revolving segment proximal to the first coupling member and a second revolving segment distal to the first coupling member. Each of the first and second revolving segments of the revolving exterior surface has a first side and a second side that is narrower than the first side. The second sides of the first and second revolving segments of the revolving exterior surface face each other. The revolving exterior surface is automation-compatible and operable by a robotic arm, facilitating automation of the first device.