Flow Analyzer Marker Synchronization for Continuous Measurement
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Solution Overview
Problem
Conventional flow analysis methods face instability and discontinuity in sample measurement due to timing discrepancies between the appearance and acquisition of analysis data peaks, particularly in systems combining analyzing devices with flow analysis methods.
Innovation Solution
A flow analyzer and method that incorporates a marker introducing device and marker detecting device to stabilize and continuously measure samples by alternately introducing markers and samples into a tube, using gas bubble segmentation and reagents, and employing heat treatment to ensure synchronized data acquisition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If flow analysis method is combined with analyzing device for continuous sample introduction, then productivity is improved, but timing synchronization between peak appearance and data acquisition deteriorates
Solution Approach 1:
A marker substance is introduced as an intermediary between the sample and the detection system. The marker travels through the same flow path as the sample and its detection signal serves as a reference for synchronizing data acquisition timing, thereby resolving the timing synchronization issue while maintaining continuous sample introduction
Solution Approach 2:
The detection signal from the marker substance is used as feedback to adjust and synchronize the data acquisition timing. By monitoring the marker's peak appearance time and using this information to trigger or adjust the acquisition window, the system maintains accurate timing synchronization during continuous operation
2Productivity
If sample viscosity and density variations occur, then measurement stability deteriorates, but continuous operation is maintained
Solution Approach 1:
The marker substance acts as a reference that is not affected by sample viscosity and density variations. By tracking the marker's position and detection signal rather than relying on fixed timing based on sample properties, the system maintains measurement stability while continuing uninterrupted operation
Solution Approach 2:
The system transitions from using fixed time-based acquisition windows to dynamic timing adjustment based on marker detection. This parameter change allows the acquisition timing to adapt to variations in flow conditions caused by different sample properties, maintaining stability throughout continuous operation
Data Source
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AI summary
Provided is a flow analyzer and a flow analysis method each of which makes it possible to stably and continuously measure a sample. The flow analyzer and the flow analysis method each include: a marker introducing device (2) which is for introducing a marker into a tube (3); and a marker detecting device (5) which detects the marker and outputs a detection signal to an analyzing device (4), the analyzing device (4) acquiring analysis data on the basis of the detection signal. (Fig. 1)