Integrated Flow Cell Layout for Compact Buffer Processing
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Solution Overview
Problem
Existing fluid management and processing systems, such as bioprocessing systems, face challenges in efficiently managing and transporting large quantities of buffer solutions, leading to a substantial footprint and operational inefficiencies.
Innovation Solution
A flow cell design with a body, inlet, outlet, and fluid flow channel, incorporating a receptacle chamber for functional elements, and tubular connectors, ensuring consistent cross-sectional flow paths and adaptability to various configurations, allowing seamless integration of sensors and mixers, and facilitating compact, efficient fluid processing systems.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If buffer solutions are made at full strength and produced in large quantities for storage in totes, then the supply of buffer solutions is sufficient for bioprocessing applications, but the system consumes a substantial footprint and requires extensive transportation space
Solution Approach 1:
The flow cell integrates multiple functional elements (sensors, mixers, flow channels) into a nested compact structure where components are arranged concentrically or in space-saving configurations, allowing sufficient buffer solution processing capacity within a reduced footprint
Solution Approach 2:
The flow cell utilizes three-dimensional space optimization by arranging flow channels and functional elements in vertical and radial dimensions rather than only linear horizontal arrangements, enabling compact integration while maintaining processing capacity
2Adaptability or versatility
If multiple buffer solutions are transported from preparation area to process suite, then the bioprocessing operations can access required buffers, but the transportation and storage requirements increase system complexity
Solution Approach 1:
The flow cell is designed as a universal platform that can accommodate multiple types of functional elements (different sensors, mixers, filters) and process various buffer solutions through a single integrated structure, eliminating the need for separate transportation systems for different buffer types
Solution Approach 2:
The flow cell merges multiple functions (buffer storage, mixing, sensing, filtration) into a single integrated unit, combining what would traditionally require separate components and transportation lines into one compact system
3Productivity
If functional elements are integrated into the flow cell body, then the fluid processing capability is enhanced, but the manufacturing complexity increases
Solution Approach 1:
The flow cell body is designed with modular segments that can be manufactured separately and then assembled, with each segment containing specific functional elements, allowing standardized manufacturing processes and reducing overall manufacturing complexity
Solution Approach 2:
The manufacturing process utilizes parameter optimization such as injection molding temperature, pressure, and material viscosity control to enable integration of functional elements during a single manufacturing step, reducing the need for post-manufacturing assembly operations
Data Source
AI summary
A flow cell for use in a fluid management and/or processing system is disclosed, said flow cell comprising a body having an inlet and an outlet and a fluid flow channel extending from the inlet to the outlet. Said body further comprises a receptacle comprising a chamber forming a part of the fluid flow channel, said chamber comprising a first opening for connecting a functional element to the flow cell such that the functional element is in contact with or exposed to a fluid flow passing through the fluid flow channel. A first tubular connector is arranged adjacent to the inlet. A second tubular connector is arranged adjacent to the outlet. The flow cell further comprises a functional element and a fluid flow path extending from the first tubular connector through the inlet, the body, the receptacle, and the outlet, to the second tubular connector.