Flow Cell Nucleic Acid Site Mapping for Real-Time Sequencing Analysis
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Solution Overview
Problem
The analysis of nucleic acid sequence data generated during sequencing processes is limited by the vast size and quantity of information, leading to challenges in speed and accuracy of data analysis.
Innovation Solution
Methods and systems for analyzing image data during nucleic acid sequencing that include time-division multiplexing or multithreading processes, allowing for simultaneous data acquisition and storage, with priority given to data acquisition over analysis, and utilizing processors to resolve conflicts and improve image analysis efficiency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If vast amounts of sequence information are obtained through massively parallel sequencing, then the quantity of sequence information is improved, but the speed and quality of analysis of sequence data deteriorates
Solution Approach 1:
The patent segments the analysis process into distinct phases: image acquisition, image analysis, and data storage. By using multiple processors to perform these phases in parallel and implementing background processing for image analysis during data acquisition, the system can handle vast amounts of sequence information without compromising analysis speed or quality.
2Device complexity
If a single processor is used for both data acquisition and analysis, then device complexity is reduced, but processing speed and accuracy deteriorate
Solution Approach 1:
The patent merges multiple processing functions into an integrated system where multiple processors work together. The system combines data acquisition processing, image analysis processing, and background processing capabilities in a unified architecture that achieves both high processing speed/accuracy and manageable complexity through coordinated multi-processor operation.
3Productivity
If image analysis is performed during data acquisition, then analysis speed is improved, but storage requirements increase
Solution Approach 1:
The patent implements preliminary image analysis during the data acquisition phase using background processing. By performing analysis operations on previously acquired images while new data is being captured, the system reduces the need for storing large volumes of raw image data, as analyzed results can be retained instead of the original high-volume image sets.
Data Source
AI summary
Methods and systems for analysis of image data generated from various reference points. Particularly, the methods and systems provided are useful for real time analysis of image and sequence data generated during DNA sequencing methodologies.