Flow Cytometry Dilution Optimization via Automated Screening

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Solution Overview

Problem

Flow cytometry instruments face challenges in accurately detecting particles at very low or high concentrations due to instrument-related, chemistry-related, and operator-related errors, leading to noise and decreased precision, especially when analyzing small particles like viruses, which requires multiple sample replicates and extensive data processing, increasing time, cost, and error potential.

Innovation Solution

The implementation of a flow cytometry system with a screening assay module to determine an optimized dilution factor range and a titer assay module to process flow cytometry results, reducing the number of samples needed and automating data processing to enhance accuracy and precision by providing operator guidance and data confirmation capabilities.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If multiple sample replicates at multiple dilutions are performed to span the dynamic range, then measurement precision is improved, but device complexity and processing time increase

Engineering Contradiction:
Improveflow cytometry result accuracyVSAvoidnumber of samples and data processing
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system performs preliminary automated analysis of flow cytometry results to determine an optimized dilution factor range before actual particle quantification. This preliminary action identifies the optimal dilution range in advance, allowing subsequent samples to be processed more efficiently without requiring extensive manual analysis of multiple dilutions.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The flow cytometry system automatically analyzes its own results to determine optimized dilution factors without requiring manual intervention. The system self-evaluates flow cytometry data, identifies patterns, and selects optimal dilution ranges autonomously, reducing the need for operator involvement and extensive manual processing.

Inventive Principle:
Principle #25Self-service

2Measurement precision

If multiple sample replicates are performed to assess intra-sample consistency, then measurement precision is improved, but loss of time increases

Engineering Contradiction:
Improveintra-sample consistencyVSAvoidprocessing time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The system uses feedback from flow cytometry results to automatically adjust and determine optimized dilution factors. By continuously analyzing results and comparing them against established criteria, the system identifies optimal dilution ranges that ensure intra-sample consistency without requiring excessive replicates, thus reducing processing time while maintaining precision.

Inventive Principle:
Principle #23Feedback

3Reliability

If automated data processing is implemented to reduce operator errors, then reliability is improved, but device complexity increases

Engineering Contradiction:
Improveoperator error reductionVSAvoiddata processing system
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The flow cytometry system performs self-service data processing by automatically analyzing flow cytometry results to determine optimized dilution factors. This automation eliminates operator errors in data processing while the system manages its own complexity through integrated software modules that handle analysis, interpretation, and recommendation generation.

Inventive Principle:
Principle #25Self-service

4Productivity

If light scatter detection is used for particle identification, then productivity is improved, but measurement precision deteriorates for small particles

Engineering Contradiction:
Improveparticle identification speedVSAvoidsmall particle detection accuracy
Core Design Contradiction:
ProductivityVSMeasurement precision

Solution Approach 1:

The system automatically determines optimized dilution factors that change the concentration parameter of particles in the sample. By adjusting dilution levels, the system optimizes the balance between particle density and detectability, enabling effective use of light scatter detection for both speed and precision, particularly for small particles where appropriate dilution enhances signal clarity.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach reduces the number of samples required, decreases processing time and computational resources, minimizes operator errors, and improves the accuracy and precision of flow cytometry investigations, making the process more efficient and cost-effective while maintaining high confidence in results.

Implementation Method 1

Scattered light or a fluorescent emission exiting from the flow cell may be detected and analyzed to provide information on the characteristics of particles present in the sample fluid

Methodology Applied
Scientific EffectLight scatter: Scattering

Implementation Method 2

The stains may have fluorescent activity that provides a fluorescent emission about a particular wavelength, the detection of which provides an indication of the presence of that biological component

Methodology Applied
Scientific EffectFluorescence: Fluorescence

Data Source

PatentEP3914896B1Flow cytometry with data analysis for optimized dilution of fluid samples for flow cytometry investigation
Publication Date: 2024.10.02 SARTORIUS BIOANALYTICAL INSTRUMENTS INC
  • EP3914896B1 patent drawingFigure 1A
  • EP3914896B1 patent drawingFigure 1B
  • EP3914896B1 patent drawingFigure 2A

AI summary

Flow cytometry investigation and flow cytometry result analysis to determine an optimized dilution factor range for flow cytometry investigation of a target sample fluid stock using a flow cytometer. The optimized dilution factor range may be determined using a screening assay module of a flow cytometry system to analyze flow cytometry results determined to fall within a dynamic range of a flow cytometer to determine the optimized dilution factor range for a given flow cytometer to investigate a given target sample fluid stock. In turn, a titer assay module may be executed to prepare particle titer results based on optimized target fluid samples provided within the optimized dilution factor range. The screening assay module and/or the titer assay module may provide automated data processing with data notifications and confirmations to provide robust data analysis.