Flow Cytometry Graphics Control for Dynamic Event Gating
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Solution Overview
Problem
Current methods for controlling graphic displays in cytometry, such as flow cytometry, are inefficient and inaccurate due to the need for manual switching between gate drawing/modification and display selection activities, leading to slowed and less accurate gate boundary positioning.
Innovation Solution
A graphics control device and method that allows for simultaneous dynamic adjustment of plot attributes like event color and style during gate drawing, triggered by user input, enabling automated or semi-automated modification of display formats based on event density and gate characteristics.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If manual switching between gate drawing and display selection activities is used, then device complexity is reduced, but productivity decreases and measurement precision deteriorates
Solution Approach 1:
The patent merges gate drawing functionality with display format selection functionality into a single integrated graphics control device. The event listener continuously monitors for both gate drawing actions and display selection commands, allowing both operations to occur within the same operational context without requiring manual switching between separate modes or devices.
Solution Approach 2:
The system dynamically adjusts plot attributes (event color, style, density) in real-time based on user input and gate characteristics. The display format automatically changes during gate drawing based on event density and user preferences, making the system adaptive rather than static, thereby improving efficiency without significant complexity increase.
2Measurement precision
If manual switching between gate drawing and display selection is required, then device complexity is minimized, but measurement precision of gate boundary positioning deteriorates
Solution Approach 1:
The event listener maintains continuous monitoring of user input throughout the gate drawing process, enabling display format changes to occur seamlessly without interrupting the gate drawing action. This continuous operation allows users to adjust display formats mid-gate-drawing, improving positioning accuracy by providing optimal visual feedback throughout the entire process rather than requiring mode switching.
Solution Approach 2:
The system automatically adjusts plot attributes based on detected gate characteristics and user input, eliminating the need for manual intervention to switch between drawing and display selection modes. The graphics control device serves itself by autonomously managing display format changes while maintaining gate drawing continuity, thereby improving precision without proportionally increasing complexity.
3Productivity
If automated modification of display formats during gate drawing is implemented, then productivity improves, but ease of operation deteriorates
Solution Approach 1:
The system provides automatic feedback by adjusting display formats based on real-time detection of gate characteristics and user input patterns. The event listener monitors ongoing operations and automatically modifies plot attributes (color, style, density) to enhance visibility and usability, allowing users to benefit from automated optimizations without requiring explicit commands for each change.
Solution Approach 2:
The system automatically changes display parameters (event color, style, plot density) based on detected conditions such as event density and user input. These parameter modifications occur dynamically during gate drawing, improving productivity by providing optimized visual feedback without requiring users to manually configure each display attribute, thereby maintaining ease of operation.
Data Source
AI summary
When manually drawing gates on plots of flow cytometric data, how the underlying data is rendered can cause inaccuracies and/or inefficiencies in the drawing. The present application is directed to graphics control features for dynamically adjusting attributes of the plot such as event color or plot style (e.g., dot plot, contour plot) while drawing a gate. The adjustments may be triggered by the gate, by the area being gated, or a trigger (e.g., mouse or key stroke event) while drawing the gate.