Flow Path Cassette Deformation Prevention
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Solution Overview
Problem
The complex assembly and connection of multiple bags and tubes in cell culture and cleaning systems for regenerative medicine are time-consuming and complicated, making it desirable to simplify the process of coupling connectors and constructing assemblies.
Innovation Solution
A disposable flow path cassette with integrated flow paths between flexible sheets, featuring a detection channel portion with bulging portions and a deformation preventative member, allows for the measurement of both positive and negative pressures, simplifying the connection and operation of cell culture and cleaning systems.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multiple bags and tubes are connected using a complex assembly of connectors, then the cell culture and cleaning systems can be constructed, but the assembly process becomes time-consuming and complicated
Solution Approach 1:
The patent combines multiple separate bags and tubes into a single integrated flow path cassette. The cassette includes a first bag, second bag, and multiple tubes pre-connected through integrated flow paths, eliminating the need for complex external connector assemblies and significantly simplifying the overall system construction.
Solution Approach 2:
The system is segmented into a modular disposable cassette unit that can be easily attached to a reusable controller. This segmentation allows the complex fluid handling functions to be contained within a single replaceable module, simplifying both assembly and maintenance.
2Ease of manufacture
If flexible sheets are used to create the flow path cassette, then the structure can be simplified and manufacturing can be easier, but the sheets may deform under pressure affecting measurement accuracy
Solution Approach 1:
The rigid support structure is selectively positioned only at the detection channel portion where pressure measurement occurs, rather than throughout the entire cassette. This localized reinforcement maintains dimensional stability at the measurement point while preserving the flexibility and ease of manufacture of the overall flexible sheet construction.
Solution Approach 2:
The cassette combines flexible sheet material with a rigid support structure to create a composite construction. This allows the structure to exhibit both the flexibility needed for easy manufacturing and the dimensional stability required for accurate pressure measurements.
3Measurement precision
If the detection channel portion is made wider to improve pressure detection, then measurement accuracy improves, but the channel becomes more prone to deformation
Solution Approach 1:
The wider detection channel portion is selectively reinforced with a rigid support structure at the specific location where pressure measurement occurs. This localized reinforcement prevents deformation of the widened channel while maintaining the measurement accuracy benefits of the increased width.
Solution Approach 2:
The rigid support structure acts as an intermediary element between the flexible detection channel and the external environment. It provides mechanical support to prevent deformation while allowing the pressure-induced deflections needed for accurate measurement to occur.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables efficient and accurate pressure measurement within the flow paths, facilitating the operation of cell culture and cleaning systems by preventing deformation and allowing for reliable detection of internal pressures, thus streamlining the process and reducing complexity.
Implementation Method 1
both positive and negative pressures acting on, or in, the flow paths to be measured
Data Source
AI summary
A flow path cassette includes superimposed first and second flexible sheets, where a plurality of flow paths are disposed therebetween and detection channel portions are disposed at one or more points along one or more of the plurality the flow paths. Each of the detection channel portions includes a first bulging portion and an opposing second bulging portion. A plate member is aligned with the second bulging portion, and a deformation preventative member is aligned with the first bulging portion. The plate member may move with the second bulging portion, while the deformation preventative member prevents deformation of the first bulging portion.