Flow Path Selection Valve for Integrated Sequencing Fluid Control
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Solution Overview
Problem
Current commercial sequencing platforms require multiple independent apparatuses for sample processing and sequencing, leading to high costs, complex operation, and limited integration, making it challenging to develop mature integrated sequencers that combine these functions effectively while maintaining performance and cost efficiency.
Innovation Solution
A fluid path system incorporating a flow path selection valve that allows independent or parallel control of multiple fluid channels, reducing the need for multiple three-way valves, thereby decreasing cost, size, reagent consumption, and improving reliability, and enabling simpler operation and maintenance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multiple independent apparatuses are used for sample processing and sequencing, then functional versatility is improved, but device complexity and cost increase
Solution Approach 1:
The patent combines multiple independent apparatuses (sample processing instrument and sequencer) into a single integrated sequencer with unified hardware and control systems. The integrated device includes integrated fluid path systems, valve assemblies, and control circuits that manage both sample preparation and sequencing operations within one platform, thereby reducing device complexity while maintaining functional versatility
Solution Approach 2:
The integrated sequencer is designed with multi-functional capabilities where a single device performs both sample processing (library construction, hybridization) and sequencing detection. The unified control system and integrated fluid path management enable one apparatus to execute multiple functions that previously required separate instruments, achieving universality without sacrificing adaptability
2Adaptability or versatility
If multiple three-way valves are used to control fluid paths, then flow path control flexibility is improved, but device complexity and size increase
Solution Approach 1:
The patent merges multiple three-way valves into a single multi-position valve assembly that can control multiple fluid paths simultaneously. The valve assembly includes a valve body with multiple ports and a valve core that can be rotated to different positions, enabling one valve to perform the function of multiple three-way valves while reducing device complexity and interlacing of tubes
Solution Approach 2:
The multi-position valve assembly is designed as a universal fluid control component that can direct fluid flow through different paths based on its rotational position. This single valve structure provides the flexibility of multiple three-way valves while maintaining a compact design, thereby improving flow path control flexibility without increasing device complexity
3Adaptability or versatility
If multiple independent apparatuses are purchased separately, then cost flexibility is improved, but ease of operation deteriorates
Solution Approach 1:
The patent integrates sample processing and sequencing functions into a single automated platform with unified control software and hardware systems. The integrated design eliminates the need for manual operations between separate apparatuses, providing automated workflow management that simplifies user operation while maintaining cost flexibility through a single purchase
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The fluid path system enables efficient integration of sample processing and sequencing functions, reducing costs and complexity, while maintaining performance and facilitating the development of compact, user-friendly integrated sequencers for nucleic acid sequence determination.
Implementation Method 1
the pump assembly induces liquid in the reservoir to flow toward the reaction device through the first flow channel
Data Source
AI summary
A liquid path system (12), comprising a flow path selection valve (10), a pump assembly (14), and a fluid network (60). The fluid network (60) comprises a reservoir (64), a first flow channel, a second flow channel, and a reaction device (62). The first flow channel and the second flow channel are each independently in flow communication with the reservoir (64) and the reaction device (62). The pump assembly (14) is in communication with the flow path selection valve (10). The pump assembly (14) is in communication with the fluid network (60). The flow path selection valve (10) is configured to rotate between a first valve position and a second valve position. In the case that the flow path selection valve (10) is at the first valve position, the pump assembly (14) induces the liquid in the reservoir (64) to flow to the reaction device (62) through the first flow channel, and in the case that the flow path selection valve (10) is at the second valve position, the pump assembly (14) induces the liquid in the reservoir (64) to flow to the reaction device (62) through the second flow channel.