One-Way Flow Restriction Mechanism for In Situ Drug Reconstitution
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing medical devices for in situ liquid drug reconstitution in medicinal vessels often cause foaming and increase dissolving time due to high-powered injection of diluent, which is inefficient for precise volume administration.
Innovation Solution
A medical device equipped with a one-way flow restriction mechanism that restricts the injection of diluent into a medicinal vessel while allowing easy aspiration of reconstituted liquid, reducing foaming and dissolving time, using a pin-like flow restrictor that reciprocates between flow restricting and non-flow restricting positions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If a sharp initial injection force is applied to overcome static friction at the syringe's gasket, then the diluent can be injected into the vial, but this causes foaming of the powder drug contents and increases dissolving time
Solution Approach 1:
A flow restrictor is introduced as an intermediary component between the syringe and vial. This flow restrictor controls and limits the injection rate of diluent, preventing direct high-speed injection that causes foaming while still allowing complete reconstitution of the powder drug contents.
2Productivity
If a high powered stream of diluent is injected into the vial, then reconstitution occurs, but the dissolving time increases compared to a slow stream
Solution Approach 1:
The flow restrictor modifies the flow parameters of the diluent injection by creating a controlled restriction that maintains a moderate injection rate. This optimized parameter allows efficient reconstitution without the excessive dissolving time associated with high-powered streams.
3Object-generated harmful factors
If the flow restrictor is designed to restrict injection flow, then foaming is minimized, but aspiration of reconstituted liquid may be restricted
Solution Approach 1:
The flow restrictor is designed with dynamic characteristics that allow it to adapt to different flow directions. The restrictor geometry enables effective flow restriction during injection while permitting adequate flow during aspiration, achieving both foaming reduction and ease of operation.
Data Source
AI summary
Medical device for in situ liquid drug reconstitution in medicinal vessels containing drug contents. The medical device includes a body member having a vessel port for insertion into a medicinal vessel containing drug contents, and a syringe port for receiving a syringe containing a diluent for reconstituting the drug contents into a reconstituted liquid drug. The medical device includes a one-way flow restriction mechanism between the two ports for positively restricting injection of diluent into a medicinal vessel and only slightly restricting aspiration of reconstituted liquid drug therefrom, if at all.