Flowable Crosslinked Collagen Hemostat for Rapid Bleeding Control
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Solution Overview
Problem
Current hemostatic products often require additional agents like thrombin and struggle to provide rapid, localized hemostasis without delaying tissue repair, and they can adhere to surgical materials, complicating their use.
Innovation Solution
A crosslinked collagen composition with controlled porosity and structure, formulated to be flowable and easily dispensable, which can be used without additional hemostatic agents, promoting rapid hemostasis and wound healing by optimizing platelet adhesion and clot formation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional hemostatic products are used, then hemostasis can be achieved, but additional hemostatic agents like thrombin are required and tissue repair may be delayed
Solution Approach 1:
The patent combines collagen matrix, platelet-rich plasma, and growth factors into a single integrated flowable composition that can be applied alone to achieve hemostasis and promote tissue repair, eliminating the need for separate thrombin applications
Solution Approach 2:
The composition serves multiple functions simultaneously: it provides hemostasis through platelet activation, delivers growth factors for tissue regeneration, and maintains a moist wound environment, replacing multiple separate products with one universal solution
2Reliability
If hemostatic products are applied to wound sites, then bleeding can be controlled, but the products may adhere to surgical materials like gauze, complicating removal
Solution Approach 1:
The composition is designed to adhere selectively to bleeding tissue surfaces through platelet-mediated bonding while maintaining compatibility with surgical materials, achieving localized adhesion where needed without unwanted attachment to gauze or other instruments
3Speed
If rapid hemostasis is achieved, then bleeding is controlled quickly, but tissue repair may be delayed
Solution Approach 1:
The composition is pre-formulated with growth factors and platelets that are primed to immediately activate upon contact with bleeding tissue, providing both rapid hemostasis and simultaneous initiation of tissue repair processes through the released growth factors
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively establishes hemostasis within minutes and supports wound healing by providing a platform for platelet adhesion and clot stabilization without adhering to surgical materials, enhancing the efficiency of medical procedures.
Implementation Method 1
assist in the rapid initiation of a hemostatic plug formed through platelet activation, aggregation, adhesion and gross clot formation
Implementation Method 2
formation of a hemostatic fibrin clot by the catalytic action of thrombin on fibrinogen
Data Source
AI summary
The invention relates to hemostatic compositions and methods for promoting hemostasis. The invention also relates to hemostatic compositions and methods for promoting wound healing. In various embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the ratio of weight percent collagen solids to weight percent crosslinker when crosslinking the collagen. In other embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the temperature and rate of freezing when drying the composition during fabrication. In some embodiments, the compositions contain additional agents, including biological agents.