Flowable Acellular Dermal Matrix for Irregular Wound Beds

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Solution Overview

Problem

Current wound treatment technologies lack effective solutions for managing acute and chronic wounds, particularly those with irregular shapes, as existing dressings fail to provide complete contact with the wound bed, hindering proper revascularization and healing.

Innovation Solution

Development of a flowable matrix composition derived from processed soft tissue, such as human dermis, which is decellularized and cryofractured to create a putty-like material that can be delivered through a syringe or cannula, providing complete contact with irregular wound beds and promoting healing by facilitating cellular infiltration and angiogenesis.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional wound dressings are used, then the wound can be covered, but complete contact with irregular wound beds cannot be achieved, hindering revascularization and healing

Engineering Contradiction:

Improvewound healing effectivenessVSAvoidcontact with irregular wound beds

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent changes the physical state and rheological properties of the matrix material from rigid to flowable/putty-like consistency, enabling it to adapt to irregular wound geometries while maintaining complete contact for effective healing

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The matrix composition is designed to be dynamically adaptable, transitioning from a moldable putty-like state during application to a stable matrix structure in the wound bed, allowing it to conform to irregular shapes while maintaining therapeutic contact

Inventive Principle:

Principle #15Dynamics

2Ease of operation

If the matrix is made flowable for easy application to hard-to-reach areas, then delivery is improved, but the material may stick to surgical instruments

Engineering Contradiction:

Improveapplication to hard-to-reach areasVSAvoidsticking to surgical instruments

Core Design Contradiction:

Ease of operationVSObject-generated harmful factors

Solution Approach 1:

The patent applies different surface property characteristics to different regions of the matrix material - the bulk material maintains flowability for easy application to hard-to-reach areas, while the surface properties are modified to prevent sticking to surgical instruments during handling and application

Inventive Principle:

Principle #3Local quality

3Adaptability or versatility

If the matrix is processed to be putty-like and pliable for complete wound contact, then adaptability is improved, but processing complexity increases

Engineering Contradiction:

Improveputty-like pliabilityVSAvoidprocessing steps

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent employs controlled parameter changes during processing, specifically adjusting temperature and humidity conditions to achieve the desired putty-like consistency from the matrix material, simplifying the overall processing approach while maintaining adaptability

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses water or hydration as an intermediary substance to achieve the putty-like consistency of the matrix material, allowing the desired pliability to be obtained through a simple addition of water rather than complex processing

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The flowable matrix composition enables enhanced wound healing by ensuring complete contact with the wound bed, promoting revascularization and angiogenesis, and can be easily applied to hard-to-reach areas without sticking to surgical instruments, thus improving treatment outcomes for complex wounds.

Implementation Method 1

cryofracturing the portion of soft tissue material. The processing protocol may provide the soft tissue matrix composition. In some instances, the soft tissue material is acellular. In some instances, the soft tissue material is at least partially decellularized.

Methodology Applied

Scientific EffectCryofracturing: Freezing

Implementation Method 2

providing complete contact with irregular wound beds and promoting healing by facilitating cellular infiltration and angiogenesis

Methodology Applied

Scientific EffectCellular infiltration:

Implementation Method 3

providing complete contact with irregular wound beds and promoting healing by facilitating cellular infiltration and angiogenesis

Methodology Applied

Scientific EffectAngiogenesis:

Data Source

PatentUS9801976B2Flowable matrix compositions and methods

Publication Date: 2017.10.31 ALLOSOURCE

AI summary

Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.