Flowable Hemostatic Paste for Minimally Invasive Surgery
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Solution Overview
Problem
Existing hemostatic compositions face challenges in achieving ease of application, especially in difficult-to-reach areas during surgical procedures, and there is a need for improved formulations that maintain hemostatic functionality without compromising consistency and adhesiveness.
Innovation Solution
A flowable hemostatic composition comprising a blend of oxidized cellulose, fibrinogen, and thrombin, dispersed in a dispersant such as glycerol and an aqueous solution, which forms a porous matrix upon application, facilitating effective hemostasis in hard-to-reach areas.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If sheets are used for hemostasis, then hemostatic performance is improved, but ease of application in minimal invasive surgeries deteriorates
Solution Approach 1:
The invention changes the physical state parameter of the hemostatic agent from solid sheet form to flowable paste form. This allows the material to be easily applied in minimally invasive surgeries while maintaining hemostatic performance through the inclusion of oxidized cellulose, fibrinogen, and thrombin in a controlled viscosity range (10-10,000 cP)
Solution Approach 2:
The invention creates a composite material system combining oxidized cellulose (for hemostatic and adhesion barrier properties), fibrinogen, and thrombin (for clot formation), dispersed in a carrier fluid. This composite approach maintains the therapeutic effectiveness of sheet-based hemostats while achieving the flowability needed for minimally invasive application
2Strength
If viscosity of hemostatic composition is increased, then adhesiveness is improved, but ease of application in hard-to-reach areas deteriorates
Solution Approach 1:
The invention optimizes the viscosity parameter to a specific range (10-10,000 cP) that balances adhesiveness and flowability. This allows the composition to adhere to bleeding surfaces while remaining sufficiently fluid for application in hard-to-reach areas during minimally invasive surgeries
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides a stable, easy-to-apply paste that accelerates clot formation and adheres to bleeding sites, effectively controlling bleeding in minimally invasive surgeries by forming a porous matrix that allows blood to percolate and promotes platelet and red cell adhesion.
Implementation Method 1
A flowable hemostatic composition comprising a blend of oxidized cellulose, fibrinogen, and thrombin, dispersed in a dispersant such as glycerol and an aqueous solution
Implementation Method 2
forming a porous matrix that allows blood to percolate and promotes platelet and red cell adhesion
Implementation Method 3
a blend of fibrinogen, thrombin, and a dispersant... accelerates clot formation
Data Source
Figure 1~2
Figure 3A~3B
Figure 3C~3D
AI summary
Disclosed herein are two-component flowable compositions comprised of: (i) a powder of: oxidized cellulose, fibrinogen and thrombin, with the weight ratio of the oxidized cellulose to the fibrinogen ranging from about 1: 5 to about 2: 1, respectively; and (ii) a dispersant comprised of glycerol and an aqueous solution, the composition being in the form of a pasty suspension at a room temperature. Also disclosed are uses of the compositions for treating a bleeding tissue, and methods for making the compositions.