Flowpack Powder Composition for Fast Release and Taste Masking
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Solution Overview
Problem
Existing oral delivery systems for bitter-tasting active pharmaceutical ingredients face challenges in providing fast release and effective taste masking, leading to delayed efficacy and adverse sensory experiences.
Innovation Solution
A flowable powder delivery system comprising distinct types of particles, including active pharmaceutical ingredients, sweeteners, and flavors, designed to synergistically enhance taste masking, mouthfeel, and saliva generation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If oral tablets are used for delivery of bitter active pharmaceutical ingredients, then taste masking is improved, but release time is delayed
Solution Approach 1:
The invention divides the oral dosage form into multiple separate particles containing active pharmaceutical ingredient, sweetener, and flavor. These particles are designed to disintegrate rapidly in the oral cavity, allowing fast release of the active ingredient while the sweetener and flavor particles provide taste masking. This segmentation enables simultaneous fast release and taste masking, resolving the contradiction between these two requirements.
Solution Approach 2:
The invention applies local quality by assigning different functions to different particles within the dosage form. The active ingredient particles are designed for rapid disintegration and release, while the sweetener and flavor particles remain as separate entities that provide taste masking. This localized functional differentiation allows fast release at the site of action while maintaining pleasant taste properties.
2Productivity
If fast release of active ingredients is achieved, then efficacy is improved, but taste masking deteriorates
Solution Approach 1:
The invention segments the dosage form into distinct particle types: active ingredient particles, sweetener particles, and flavor particles. The active ingredient particles are designed to disintegrate rapidly for fast release, while the separate sweetener and flavor particles provide taste masking. This segmentation allows the system to achieve both fast release and effective taste masking simultaneously, resolving the contradiction between release rate and taste masking.
Solution Approach 2:
The invention introduces sweetener and flavor particles as intermediary substances that mediate between the fast release of active ingredients and the prevention of bitter taste. These intermediary particles are dispersed throughout the dosage form and work together with the rapidly disintegrating active ingredient particles to provide both fast release and taste masking effects.
3Manufacturing precision
If tablet formulation is used, then uniformity of content is improved, but device complexity increases
Solution Approach 1:
The invention segments the formulation into separate particle types that can be manufactured independently and then combined. This approach maintains uniformity of content through controlled mixing while reducing formulation complexity compared to traditional tablet methods. The segmented particle approach allows for simpler manufacturing processes and easier quality control.
Solution Approach 2:
The invention changes the physical state and formulation parameters by using separate particles instead of compressed tablet material. This parameter change simplifies the formulation process while maintaining uniformity of content through controlled particle distribution. The particle-based approach allows for flexible dosing and simplified manufacturing.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system achieves fast release of active ingredients with improved taste masking, enhanced mouthfeel, and increased saliva generation, providing superior convenience and effectiveness in delivering active pharmaceutical ingredients.
Implementation Method 1
a second type of particles in an amount of 30-95% by weight of the population of particles separate from the first type of particles, the second type of particles comprising at least 95% by weight of one or more sweeteners... providing superior convenience and effectiveness in delivering active pharmaceutical ingredients
Implementation Method 2
enhanced mouthfeel, and increased saliva generation, providing superior convenience and effectiveness in delivering active pharmaceutical ingredients
Data Source
AI summary
A powder delivery system that is not in tablet form but contained in a flowpack. There is provided a flowpack for oral delivery of active pharmaceutical ingredients comprising a flowable population of particles including different types of particles where the particles comprise a first type of particles comprising one or more distinct portions of particles with a content of one or more active pharmaceutical ingredients and a carrier for the one or more active pharmaceutical ingredients, a second type of particles in an amount of 30-95% by weight of the population of particles separate from the first type of particles, the second type of particles comprising at least 95% by weight of one or more sweeteners, and a third type of particles in an amount of 1-10% by weight of the population of particles separate from the first and second type of particles, the third type of particles comprising flavor.