Fluensulfone Synthesis via Low-Temp Catalytic Oxidation
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Solution Overview
Problem
Current processes for preparing fluensulfone, a potent nematicide, face challenges such as low yield, selectivity, and waste generation due to high temperatures and the use of expensive oxidizing agents like oxone, which are problematic especially in large-scale production.
Innovation Solution
A catalytic oxidation process at low temperatures using an oxidizing agent and a catalyst, such as sodium tungstate, to convert 5-chloro-2-[(3,4,4-trifluoro-3-buten-1-yl)thio]-thiazole into fluensulfone, optimizing reaction conditions to achieve high selectivity and yield while minimizing waste.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If high temperature oxidation is used to convert sulfide to sulfone, then reaction rate is improved, but selectivity deteriorates and yield decreases
Solution Approach 1:
The patent applies parameter changes by conducting the oxidation reaction at low temperatures (0-25°C) instead of high temperatures, which improves selectivity and yield while maintaining acceptable reaction rates through the use of a catalyst system comprising sodium tungstate and phosphoric acid
2Productivity
If expensive oxidizing agents like oxone are used, then oxidation efficiency is improved, but production cost increases and waste generation increases
Solution Approach 1:
The patent replaces expensive oxidizing agents like oxone with cheaper alternatives such as hydrogen peroxide or sodium percarbonate, which are more cost-effective for large-scale production while maintaining oxidation efficiency through the catalytic system
Solution Approach 2:
The patent reduces waste generation by using oxidizing agents that produce fewer salts and bypires the catalyst system that can be more easily handled and disposed of compared to oxone, reducing the environmental burden and waste treatment costs
3Device complexity
If conventional oxidation methods are used, then process simplicity is maintained, but yield and selectivity are low
Solution Approach 1:
The patent introduces a catalyst system comprising sodium tungstate and phosphoric acid as intermediaries that mediate the oxidation reaction, enabling high yield and selectivity under mild conditions while maintaining process simplicity through the use of readily available chemicals and straightforward reaction conditions
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process achieves high conversion rates and chemical yields, reduces production costs, and minimizes salt waste, providing a more efficient and selective method for producing fluensulfone.
Implementation Method 1
reacting a compound of formula (II) with an oxidizing agent and a catalyst at a low temperature
Implementation Method 2
preparing fluensulfone by the reaction of the corresponding sulfide with an oxidizing agent
Data Source
AI summary
The present invention provides a process for preparing a compound of formula [I] from a compound of formula [II] using an oxidizing agent and a catalyst, the process is carried out at a low temperature.