Fluid Handling Function Checks Using Integrated Level Sensing
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Solution Overview
Problem
Existing fluid handling systems require manually intensive operations for function checks, including the use of analytical balances and microplate readers, which are costly and require operator intervention, and involve reprogramming the system, consuming significant time and resources.
Innovation Solution
Incorporating native level sensing capabilities into the fluid handling system to perform function checks with minimal or no operator interaction, using imaging devices and capacitance sensors to accurately measure fluid levels and volumes, thereby verifying the operation of fluid dispensers and pipette tips.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional function checks using analytical balances and microplate readers are performed, then measurement precision is improved, but device complexity and operator intervention requirements increase
Solution Approach 1:
The patent extracts the measurement function from external complex devices (analytical balances, microplate readers) and integrates it directly into the fluid handling system through built-in imaging devices and capacitance sensors. This allows volume measurement to be performed within the fluid handling system itself, eliminating the need for separate measurement devices and reducing overall system complexity.
Solution Approach 2:
The fluid handling system is designed to perform multiple functions using integrated components. The imaging device and capacitance sensor serve dual purposes: they are used for both fluid level detection during normal operation and for volume measurement during function checks. This multi-functionality eliminates the need for separate dedicated measurement equipment.
2Measurement precision
If traditional function checks with analytical balances and microplate readers are used, then measurement precision is improved, but loss of time increases due to manual operations
Solution Approach 1:
The system performs function checks automatically using its own integrated imaging device and capacitance sensor without requiring external equipment or manual operator intervention. The fluid handling system checks itself by automatically measuring fluid levels and calculating volumes, eliminating the time-consuming manual operations of transferring samples to external devices and performing manual readings.
Solution Approach 2:
The system performs function checks as a preliminary automated step before actual fluid handling operations. By integrating the measurement capability directly into the system, function checks can be performed quickly and automatically without requiring subsequent manual intervention or transfer of samples to external devices, significantly reducing total time required.
3Measurement precision
If manual function check operations are performed, then measurement precision is improved, but ease of operation deteriorates
Solution Approach 1:
The system automatically performs function checks using its own integrated imaging device and capacitance sensor. The controller automatically captures images, measures fluid levels, calculates volumes, and compares results to expected values without requiring operator intervention. This self-service capability eliminates the need for operators to manually transfer samples, operate external devices, or record measurements.
Solution Approach 2:
The system provides automatic feedback by comparing measured volumes to expected target volumes and indicating whether the function check passed or failed. This automated feedback loop eliminates the need for operators to manually compare measurements and interpret results, significantly improving ease of operation while maintaining measurement precision.
4Measurement precision
If traditional function check methods are used, then measurement precision is improved, but loss of time increases due to reprogramming requirements
Solution Approach 1:
The patent extracts the measurement and calculation functions from external devices and integrates them directly into the fluid handling system's controller. The controller uses the imaging device and capacitance sensor to automatically measure fluid levels and calculate volumes using integrated algorithms, eliminating the need for external measurement devices and the reprogramming time associated with setting up external equipment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables automated and efficient function checks without the need for manual intervention, reducing time and costs associated with traditional methods, while ensuring accurate calibration and operation of fluid handling systems.
Implementation Method 1
obtain an image of the container using an imaging device
Implementation Method 2
capacitance sensors to accurately measure fluid levels and volumes
Data Source
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AI summary
A method for performing a function check of a fluid handling system can comprise dispensing a first reference dose of a fluid into a reference container using a first fluid dispenser, measuring a first fluid height of the first reference dose in the reference container with a fluid level sensing system of the fluid handling system, and changing a status of the fluid handling system based on the first measured first fluid height. Robotic fluid handling system can comprise controllers and computer readable memory configured to execute the methods described herein.