Fluid Supply Device with Elastic Buffer for HPLC Pressure Stability

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Solution Overview

Problem

In high-performance liquid chromatography (HPLC) and other sample separation applications, existing fluid supply devices face challenges in precisely forming a mobile phase due to volume errors in mixing fluids, leading to inaccuracies in solvent composition and potential pressure fluctuations.

Innovation Solution

The implementation of a fluid supply device with an elastic buffer unit upstream of the fluid valve to dampen pressure fluctuations, combined with an integrally formed fluid member for precise fluid combining and mixing, and a compensating volume to prevent reflow, ensures accurate solvent composition and extended valve lifespan.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If an elastic buffer unit is added upstream of the fluid valve to dampen pressure fluctuations, then pressure stability is improved, but device complexity increases

Engineering Contradiction:
Improvepressure stabilityVSAvoiddevice complexity
Core Design Contradiction:
Stability of the object's compositionVSDevice complexity

Solution Approach 1:

The elastic buffer unit acts as an intermediary element between the fluid supply conduit and the fluid valve. It absorbs pressure fluctuations and dampens pulses before they reach the valve, thereby stabilizing pressure without requiring complex control systems. The buffer unit mediates the interaction between the fluid source and valve, preventing direct transmission of pressure shocks.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The elastic buffer unit changes the physical parameters of the fluid system by introducing elasticity and volume compliance. It allows temporary expansion and contraction of the buffer volume to absorb pressure variations, transforming abrupt pressure changes into smoother, more stable pressure profiles before the fluid reaches the valve.

Inventive Principle:
Principle #35Parameter changes

2Duration of action of stationary object

If a compensating volume is introduced to prevent reflow, then valve lifespan is improved, but device complexity increases

Engineering Contradiction:
Improvevalve lifespanVSAvoiddevice complexity
Core Design Contradiction:
Duration of action of stationary objectVSDevice complexity

Solution Approach 1:

The compensating volume is designed beforehand to accommodate potential reflow of fluid from the fluid conveying unit. This pre-configured volume acts as a cushion that prevents reflowing fluid from reaching and damaging the fluid valve seals. By providing this protective volume in advance, the system prevents valve degradation and extends valve lifespan without requiring active control mechanisms.

Inventive Principle:
Principle #11Beforehand cushioning (Prior cushioning)

3Manufacturing precision

If an integrally formed fluid member is used for precise fluid combining and mixing, then manufacturing precision is improved, but device complexity increases

Engineering Contradiction:
Improvefluid mixing precisionVSAvoiddevice complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The fluid combining unit and mixing unit are merged into a single integrally formed fluid member. This integration ensures precise fluid combining and mixing by eliminating connection errors and ensuring accurate fluid paths. The unified structure guarantees that the compensating volume is precisely positioned and dimensioned, achieving high manufacturing precision while reducing the number of separate components.

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This solution enhances the precision of the mobile phase composition, prevents undesired pressure pulses, and extends the lifespan of fluid valves by ensuring accurate solvent mixing and preventing reflow, thereby improving the reliability and performance of HPLC systems.

Implementation Method 1

an elastic buffer unit which is fluidically coupled upstream of the fluid valve with the supply conduit and which is configured for buffering the fluid

Methodology Applied
Scientific EffectElasticity: Elasticity

Implementation Method 2

an elastic buffer unit which is fluidically coupled upstream of the fluid valve with the supply conduit and which is configured for buffering the fluid

Methodology Applied
Scientific EffectPressure fluctuation damping: Damping

Implementation Method 3

a mixing unit for mixing the combined fluids and for providing the mixed fluids as mobile phase at a fluid outlet

Methodology Applied
Scientific EffectFluid mixing:

Implementation Method 4

between the fluid valves and the combining position, a such dimensioned compensating volume is formed, that even in the case of a maximum fluid reflow from the fluid conveying unit in the direction of the fluid valves, reaching the fluid valves by the fluid reflow is made impossible due to the compensating volume

Methodology Applied
Scientific EffectFluid reflow prevention:

Data Source

PatentUS12000808B2Fluid supply devices and fluid member for forming a mobile phase for a sample separating device
Publication Date: 2024.06.04 AGILENT TECHNOLOGIES INC
  • US12000808B2 patent drawing
  • US12000808B2 patent drawing
  • US12000808B2 patent drawing

AI summary

A fluid supply device for providing a mobile phase for a sample separating device includes, a supply conduit for providing a fluid which forms at least a part of the mobile phase, a fluid valve which is fluidically coupled with the supply conduit and, depending on its switching state, enables or prevents a passing of the fluid from the supply conduit, an elastic buffer unit which is fluidically coupled upstream of the fluid valve with the supply conduit and which is configured for buffering the fluid, and a fluid conveying unit for conveying the fluid which passes the fluid valve.