Fluid Supply System Mobile Phase Composition Accuracy
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Solution Overview
Problem
The challenge in liquid chromatography is providing a mobile phase with a precisely defined composition, as existing systems struggle with uncontrollable phenomena such as diffusion at fluid interfaces and residual solvent components in the fluid drive unit, leading to undefined portions of the mobile phase.
Innovation Solution
A fluid supply system comprising a proportioning unit to mix multiple solvent components, a fluid drive unit to drive the mobile phase, and a control unit to manage the proportioning and driving processes, ensuring that undefined portions of the mobile phase are identified and removed before reaching the separation path.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multiple solvent components are proportioned and mixed to create a mobile phase, then the mobile phase can be composed of different solvent ratios, but diffusion at fluid interfaces creates undefined portions with unpredictable composition
Solution Approach 1:
The patent removes the undefined portion of mobile phase that contains diffusion artefacts at fluid interfaces. A defined volume of mobile phase is discarded to eliminate the contaminated section, ensuring that only the well-defined composition reaches the separation path. This directly addresses the contradiction by sacrificing a portion of the mobile phase to preserve composition accuracy.
Solution Approach 2:
The patent performs preliminary removal of the undefined portion before the mobile phase enters the separation path. By proactively discarding the contaminated section in advance, the system ensures that only the precisely defined composition portion is used for actual separation, preventing diffusion artefacts from affecting the analysis.
2Stress or pressure
If a fluid drive unit compresses and delivers mobile phase, then the mobile phase can be delivered at required pressure, but residual solvent in the piston chamber creates undefined portions
Solution Approach 1:
The patent extracts and removes the residual solvent portion from the piston chamber before the mobile phase is delivered to the separation path. This ensures that the undefined composition caused by residual solvent does not contaminate the main mobile phase flow, maintaining composition accuracy while preserving the required delivery pressure capability.
3Productivity
If the fluid supply system operates continuously, then productivity is maintained, but uncontrollable phenomena continuously generate undefined portions
Solution Approach 1:
The patent implements a rapid removal of the undefined portion through the waste conduit during continuous operation. The system quickly discards the contaminated section and transitions to delivering the well-defined composition, minimizing the impact on overall productivity while ensuring composition accuracy is maintained throughout continuous operation.
4Ease of manufacture
If diffusion artefacts are allowed to occur at fluid interfaces, then the fluid mixing process is simpler, but the composition becomes unpredictable and undefined
Solution Approach 1:
The patent removes the undefined portion containing diffusion artefacts from the mobile phase stream. By discarding this contaminated section, the system maintains the simple mixing process while eliminating the harmful effect of unpredictable composition at fluid interfaces, achieving both ease of manufacture and manufacturing precision.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach significantly improves the accuracy, precision, and reproducibility of forming a solvent composition as a mobile phase, enhancing the separation accuracy of the sample separation device by ensuring a well-defined mobile phase composition.
Implementation Method 1
due to uncontrollable phenomena in the fluid supply system. One example of such undefined portions of mobile phase are fluid interfaces between different fluid packets of different solvent components directly adjacent to one another in a conduit or flow path, where not properly predictable diffusion artefacts or the like may occur
Data Source
AI summary
A fluid supply system, for supplying a mobile phase in a sample separation device for separating a fluidic sample in a separation path, includes a proportioning unit for proportioning multiple solvent components for composing the mobile phase, a fluid drive unit for driving the solvent components of the mobile phase, and a control unit for controlling the proportioning unit and the fluid drive unit so that an undefined portion of the mobile phase is removed from the mobile phase before delivering the mobile phase from the fluid drive unit to the separation path.