Fluidic Bead Trap with Movable Ports for Faster Sample Preparation
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Solution Overview
Problem
Current sample preparation technologies lack efficiency in capturing and treating target agents while they are captured with a capture agent, and in obtaining the captured target agents from the capture agent, necessitating improvements for faster and better sample preparation processes.
Innovation Solution
A fluidic device with movable transport bodies that can align with different fluid conduits to couple or isolate them, allowing for the capture, treatment, and release of target materials using magnetic particles and a magnetic source, enabling the movement of magnetic particles between conduits for interaction with various reagents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If traditional separation devices and techniques are used to selectively remove desired substances from samples, then substance isolation can be achieved, but the sample preparation process is slow and inefficient
Solution Approach 1:
The transport body is made movable between different fluid conduits, allowing dynamic reconfiguration of fluid pathways. This enables the system to quickly transition between different operational modes (capture, treatment, release) without requiring multiple separate devices, thereby accelerating sample preparation while maintaining isolation efficiency
Solution Approach 2:
A single transport body serves multiple functions by being movable between different fluid conduits. The same transport body can capture target agents in one conduit, transfer them to another conduit for treatment, and then release them when needed. This multi-functionality eliminates the need for multiple separate devices, improving productivity without sacrificing separation capability
2Adaptability or versatility
If multiple separate devices are used for capturing, treating, and releasing target agents, then each function can be performed independently, but the device complexity increases
Solution Approach 1:
The transport body is designed as a universal component that can interact with multiple different fluid conduits. By moving the transport body between conduits, the system achieves the functionality of multiple separate devices (capture device, treatment device, release device) using a single multi-functional component, thereby reducing overall device complexity while maintaining adaptability
Solution Approach 2:
The system merges the functions of capturing, treating, and releasing target agents into a single integrated system. The transport body acts as a common interface that connects different fluid conduits, allowing all operations to be performed within one device rather than requiring multiple separate devices, thus simplifying the overall system architecture
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables efficient capture, treatment, and release of target materials, improving sample preparation by allowing for selective alignment of conduits and reagents, enhancing purification and analysis capabilities.
Implementation Method 1
at least one magnetic member magnetically associated with the at least one port
Data Source
AI summary
A fluidic device can include: a plurality of fluid conduits, each fluid conduit including a first conduit portion separated from a second conduit portion; and at least one transport body that is movably positioned between the first conduit portion and the second conduit portion of each fluid conduit. The at least one transport body can include: at least one port adapted to be aligned with a first conduit portion and a second conduit portion of at least one first conduit so as to fluidly couple the first conduit portion with the second conduit portion; and at least one blocking body portion adapted to be aligned with a first conduit portion and a second conduit portion of at least one second conduit so as to fluidly isolate the first conduit portion from the second conduit portion of the at least one second conduit.