Fluidic Cartridge Module for Biosensor Analyte Detection
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Solution Overview
Problem
Current biosensor technologies face challenges in efficiently and reliably delivering biological samples to sensing areas, often resulting in wastage of fluid samples and requiring complex, maintenance-intensive pump systems for fluid delivery.
Innovation Solution
A biosensor device incorporating a fluidic cartridge module with integrated sample and buffer inlets, a biosensor package featuring a sensor array and reference electrode, and a fluidic channel that allows for controlled fluid flow over the biosensor chip, enabling efficient sample detection and analysis without the need for complex pump systems.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If manual pipetting is used to deliver fluid sample to sensing area, then sample delivery is simple to perform, but large portion of fluid sample is wasted and process is time consuming
Solution Approach 1:
The device divides the sensing area into multiple discrete sensing zones, each capable of being individually addressed and controlled. This segmentation allows precise delivery of fluid to only the necessary sensing areas, reducing overall fluid consumption while maintaining operational simplicity through automated control of individual zones.
Solution Approach 2:
The patent replaces manual mechanical pipetting with an automated fluid delivery system that uses electrical control to manage fluid flow to sensing areas. This substitution eliminates the waste associated with manual pipetting while maintaining ease of operation through automated sequencing and control.
2Extent of automation
If pump systems are used to deliver fluid through tubing to sensor area, then fluid delivery is automated, but systems become highly reliant on precise operation of pumps and valves and are difficult to maintain as they become smaller
Solution Approach 1:
The patent extracts and eliminates the pump and valve components from the fluid delivery system. By removing these complex mechanical elements, the system achieves automated fluid delivery through alternative means that are inherently more reliable and easier to maintain, particularly in miniaturized configurations.
Solution Approach 2:
The fluid delivery system is designed to be self-regulating and self-actuating, using the fluid's own properties and integrated control mechanisms within the cartridge itself to manage flow without external pumps or valves. This self-service approach automates delivery while eliminating maintenance-prone components.
3Adaptability or versatility
If multiple sensing areas are present on biosensor, then detection capability is enhanced, but manual loading of each sensing area becomes time consuming
Solution Approach 1:
The sensing area is divided into multiple independent sensing zones that can be individually activated and controlled. This segmentation enables enhanced detection capability across multiple zones while allowing automated sequential loading and analysis, eliminating the time-consuming manual loading of each area.
Solution Approach 2:
The system implements continuous automated operation where fluid delivery, sensing, and analysis proceed seamlessly across multiple sensing areas without manual intervention between zones. This continuous operation maintains enhanced detection capability while eliminating idle time between loading operations.
Data Source
AI summary
A fluidic cartridge module includes a casing, a biosensor package, and a fluidic channel. The casing includes a sample inlet and a buffer inlet, a biosensor package disposed in the casing and comprising a sensor array and a reference electrode. The fluidic channel is disposed over the biosensor package and connected to the sample inlet and the buffer inlet, wherein the fluidic channel includes a first opening aligned with the sensor array and a second opening aligned with the reference electrode.