Fluidic Method Transfer via Real Operation Mode Derivation
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Solution Overview
Problem
Conventional operation mode adjustment systems for fluidic devices, such as liquid chromatography apparatuses, are cumbersome and often ignore dwell volume considerations, leading to tedious and error-prone method development and transfer processes.
Innovation Solution
A system and method for deriving and converting an operation mode from one fluidic device configuration to another, using determining units to calculate real operation modes based on target modes and preknown parameterization, allowing for accurate adaptation and transfer of certified methods between devices, including consideration of dwell volumes and physical effects like friction and velocity profiles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional operation mode adjustment systems are used for fluidic devices, then device operation can be achieved, but the process becomes cumbersome and error-prone due to ignoring dwell volume considerations
Solution Approach 1:
The system performs preliminary determination of the real operation mode of the first fluidic device based on its target operation mode and preknown parameterization before transferring to the second device. This advance calculation of real operational characteristics including dwell volume effects enables accurate method transfer without cumulative errors
Solution Approach 2:
The apparatus introduces an intermediary computational layer that translates between target operation modes and real operation modes. This intermediary processing unit calculates the actual operational behavior considering physical constraints like dwell volume, serving as a mediator between ideal method specifications and real device performance
2Ease of operation
If dwell volume considerations are ignored in method transfer, then the transfer process is simpler, but the accuracy and reliability of the transferred method deteriorates
Solution Approach 1:
The system automatically adjusts operational parameters when transferring methods between fluidic devices. The determining units calculate modified target operation modes for the second device based on the first device's real operation mode and the second device's preknown parameterization, automatically compensating for differences in dwell volume and other physical characteristics without manual intervention
Solution Approach 2:
The patent replaces manual, iterative method transfer procedures with an automated computational system. The apparatus uses determining units to automatically calculate and derive operation modes, substituting the mechanical/Manual adjustment process with an automated algorithmic approach that inherently accounts for dwell volume and physical effects
3Reliability
If automated determination of real operation modes is implemented, then method transfer accuracy improves, but computational complexity increases
Solution Approach 1:
The computational process is segmented into distinct functional units: a first determining unit that calculates the real operation mode of the first device, and a second determining unit that derives the target operation mode for the second device. This segmentation of the computational task into modular, specialized units manages complexity by breaking down the overall problem into manageable, independent calculation stages
Data Source
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AI summary
An apparatus (200) for deriving an operation mode from a first fluidic device to a second fluidic device, wherein the first fluidic device has a first target operation mode (300) representing a desired behavior of the first fluidic device and has a first real operation mode (304) representing the actual behavior of the first fluidic device, wherein the second fluidic device has a second target operation mode (312) representing a desired behavior of the second fluidic device and has a second real operation mode (314) representing the actual behavior of the second fluidic device, the apparatus (200) comprising a first determining unit (202) adapted for determining the first real operation mode (304) based on the first target operation mode (300) and based on a preknown parameterization (302) of the first fluidic device, and a second determining unit (204) adapted for determining the second target operation mode (312) based on the determined first real operation mode (304) and based on a preknown parameterization (306) of the second fluidic device.