Fluidic Multiplexer Layout for Compact Multi-Channel Flow Control

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Solution Overview

Problem

Microfluidic devices face challenges in efficiently managing and controlling the flow of multiple fluids through numerous fluidic channels, requiring complex control systems that are often bulky and data-intensive.

Innovation Solution

The integration of a fluidic multiplexer (FMUX) with thermo-pneumatic fluidic micro-valves and control lines allows for selective control of fluid flow through a large number of channels using a compact design, minimizing data inputs and device size by employing thermal expansion and contraction to open and close fluidic channels.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If complex control systems are used to manage and control fluid flow through numerous fluidic channels, then fluid flow control capability is improved, but device size and data requirements increase

Engineering Contradiction:
Improvefluid flow control capabilityVSAvoidcontrol system complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The control line is designed to serve multiple functions: it acts as a thermal conduction path for actuating multiple micro-valves sequentially, serves as a structural support element, and enables time-multiplexed control of numerous fluidic channels through a single input line, thereby reducing overall system complexity while maintaining versatile fluid flow control

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The system employs dynamic sequential actuation where micro-valves are opened and closed in a time-multiplexed sequence along the control line. This dynamic approach allows a single control line to control multiple channels at different time intervals, replacing what would otherwise require multiple simultaneous control lines, thus reducing device complexity

Inventive Principle:
Principle #15Dynamics

2Speed

If thermo-pneumatic micro-valves are used to control fluid flow, then valve actuation speed is improved, but energy consumption increases

Engineering Contradiction:
Improvevalve actuation speedVSAvoidenergy consumption
Core Design Contradiction:
SpeedVSUse of energy by moving object

Solution Approach 1:

The control line delivers periodic thermal pulses to sequentially actuate micro-valves along the fluidic channel. Each thermal pulse opens a specific valve for a brief period to allow fluid passage, then the pulse is withdrawn and the valve closes. This periodic thermal action enables rapid valve switching while minimizing total energy consumption compared to continuous heating

Inventive Principle:
Principle #19Periodic action

Solution Approach 2:

The micro-valves utilize thermal expansion of the channel material or trapped gas when heated by the control line to open the valve, and thermal contraction when cooling to close the valve. This thermally-driven mechanical motion provides rapid actuation speed while the localized and temporary nature of heating minimizes overall energy consumption

Inventive Principle:
Principle #37Thermal expansion

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This solution enables complex fluid manipulation with exponential processing ability while reducing the size and data requirements for controlling fluid flow, making it suitable for applications like DNA synthesis and parallel testing.

Implementation Method 1

employing thermal expansion and contraction to open and close fluidic channels

Methodology Applied
Scientific EffectThermal expansion: Thermal Expansion

Implementation Method 2

employing thermal expansion and contraction to open and close fluidic channels

Methodology Applied
Scientific EffectThermal contraction: Thermal Contraction

Data Source

PatentUS11794186B2Microfluidic devices including fluidic multiplexers
Publication Date: 2023.10.24 HEWLETT PACKARD DEVELOPMENT COMPANY LP
  • US11794186B2 patent drawing
  • US11794186B2 patent drawing
  • US11794186B2 patent drawing

AI summary

An example microfluidic device comprises a plurality of fluidic channels and a fluidic multiplexor. The fluidic multiplexor includes a plurality of fluidic micro-valves fluidically coupled to the plurality of fluidic channels, and a plurality of control lines that cross the plurality of fluidic channels proximal to the plurality of fluidic micro-valves.