Fluorescence Spectral Analyte Testing for Non-Invasive Precision
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Solution Overview
Problem
Existing analyte testing technologies face challenges such as invasiveness, high cost, complexity, and difficulty in achieving real-time, portable, and accurate non-invasive measurements due to issues like mixed spectral signals and interference from skin components.
Innovation Solution
A method and system using broad-spectrum visible and near-infrared light imaging to distinguish between areas with and without blood vessels, selecting testing and reference points based on grayscale distribution, and utilizing fluorescence spectroscopy to obtain and analyze reflection spectral data through a trained model for accurate analyte concentration measurement.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If Raman spectroscopy is used for non-invasive analyte measurement, then measurement precision is improved, but device complexity and cost increase significantly
Solution Approach 1:
The patent changes the fundamental measurement parameter from Raman scattering to fluorescence emission. By using fluorescence spectroscopy instead of Raman spectroscopy, the system achieves comparable measurement precision for analyte concentration while dramatically reducing device complexity and cost, as fluorescence detection uses simpler optical components and detectors
Solution Approach 2:
The patent replaces the complex mechanical and optical alignment requirements of Raman spectroscopy with a more straightforward fluorescence detection system. The fluorescence-based approach eliminates the need for complex laser systems and precise optical path alignment, substituting them with simpler excitation light sources and detection mechanisms
2Ease of operation
If absorption spectroscopy is used for non-invasive testing, then non-invasive measurement is achieved, but measurement precision deteriorates due to mixed spectral signals
Solution Approach 1:
The patent extracts and isolates the fluorescence signal specific to the analyte from the complex mixed spectral signals. By using fluorescence spectroscopy with specific excitation wavelengths and detecting emission at characteristic wavelengths, the system separates the analyte signal from background interference from skin components, achieving both non-invasive operation and high measurement precision
Solution Approach 2:
The patent introduces fluorescence as an intermediary phenomenon between light interaction and analyte detection. The analyte molecules act as fluorescent intermediaries that absorb excitation light and emit characteristic fluorescence, providing a clear spectral signature that distinguishes them from surrounding tissue components, thereby improving measurement precision while maintaining non-invasive operation
3Loss of information
If multiple sensors and modules are used for comprehensive signal collection, then information completeness is improved, but device complexity and cost increase
Solution Approach 1:
The patent makes the imaging module multi-functional by enabling it to perform both structural imaging and fluorescence spectral detection using the same optical path. The imaging module captures reflected light for anatomical structure visualization while simultaneously collecting fluorescence signals for analyte concentration measurement, eliminating the need for separate dedicated sensors and reducing overall system complexity
Solution Approach 2:
The patent merges the imaging function and spectral detection function into a single integrated system. By combining the imaging module with fluorescence detection capabilities, the system collects both structural and biochemical information through one unified platform, reducing the number of separate components while maintaining comprehensive information acquisition
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables non-invasive, cost-effective, and real-time analyte testing with high accuracy by distinguishing vessel areas, excluding non-analyte influences, and correlating spectral data directly with analyte concentration without requiring electrochemical reactions.
Implementation Method 1
irradiating a first area by broad-spectrum visible light/broad-spectrum near-infrared light within a first wavelength range and imaging the first area, to obtain a first image of an imaging area
Implementation Method 2
irradiating the first area by ultraviolet light and exciting fluorescence, to obtain fluorescence spectral data
Data Source
AI summary
The present invention provides a method and a system for testing an analyte, a medium, and a device, including: imaging: irradiating a first area by broad-spectrum visible light/broad-spectrum near-infrared light within a first wavelength range and imaging the first area, to obtain a first image of an imaging area; and irradiating the first area by broad-spectrum near-infrared light/broad-spectrum visible light within a second wavelength range and imaging the first area, to obtain a second image of the imaging area; spectral obtaining: obtaining, from the first image, color or grayscale distribution data that indicate the analyte; and based on the color or grayscale distribution data, respectively obtaining, from the first image and the second image, reflection spectral data at desired positions that demonstrate the analyte; and analyzing: obtaining information about the analyte in the imaging area based on the obtained reflection spectral data.