Fluorescence Spectrum Collection for Non-Invasive Glucose Sensing
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current non-invasive blood glucose testing methods face challenges such as high costs, poor biocompatibility, susceptibility to interference, and the inability to perform frequent and continuous testing due to interference from skin and subcutaneous tissues.
Innovation Solution
A method and system utilizing infrared and ultraviolet light to collect fluorescence spectra by imaging and selecting testing and reference points based on grayscale distribution, enabling simultaneous collection of vascular and non-vascular area data to reduce interference and achieve accurate glucose concentration measurement.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If Raman spectroscopy is used to detect blood glucose, then measurement precision is improved, but device complexity and cost increase due to requiring laboratory-grade systems
Solution Approach 1:
The patent replaces Raman spectroscopy with fluorescence spectroscopy, substituting one optical detection method with another that uses different physical principles. This allows the use of simpler, more compact equipment while maintaining measurement capability for blood glucose concentration
Solution Approach 2:
The patent changes the detection parameter from Raman scattering signals to fluorescence emission signals. By using fluorescence spectroscopy with specific excitation wavelengths, the system achieves blood glucose measurement with simpler and more cost-effective equipment compared to laboratory-grade Raman systems
2Ease of operation
If only blood vessel position is tested, then testing process is simplified, but measurement precision deteriorates due to interference from skin and subcutaneous tissues
Solution Approach 1:
The patent segments the detection area into multiple regions of interest based on grayscale distribution in the captured image. By identifying and selecting specific ROIs that correspond to blood vessel locations while excluding surrounding tissue, the system separates the target signal from interfering signals, improving measurement precision without significantly complicating the testing process
Solution Approach 2:
The patent applies different processing strategies to different regions of the image. By analyzing grayscale distribution to identify blood vessel areas versus surrounding tissue areas, the system selectively processes only the relevant regions for glucose measurement, thereby maintaining operational simplicity while enhancing measurement accuracy through localized signal extraction
3Measurement precision
If invasive testing methods are used, then measurement precision is improved, but ease of operation and biocompatibility worsen due to poor compliance and high costs
Solution Approach 1:
The patent replaces invasive mechanical blood sampling with non-invasive optical detection. By using fluorescence spectroscopy to detect blood glucose through the skin, the system eliminates needles and consumables, dramatically improving patient compliance and enabling frequent continuous monitoring while maintaining measurement precision
Solution Approach 2:
The patent introduces optical fields (light) as an intermediary to transmit information about blood glucose concentration from the interior of the body to external detectors. This intermediary approach allows non-invasive measurement by detecting fluorescence signals that carry glucose concentration information without direct contact with blood, thereby improving ease of operation and biocompatibility
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method allows for accurate, real-time, and cost-effective non-invasive glucose testing by minimizing interference and utilizing fluorescence spectroscopy, reducing the need for invasive methods and providing high signal-to-noise ratios.
Implementation Method 1
irradiating a first area by infrared light, and imaging the first area, to obtain a first image of an imaging area
Implementation Method 2
irradiating the first area by ultraviolet light, and imaging the first area based on an excited fluorescent radiation signal, to obtain a second image of the imaging area
Data Source
Figure 1~2
Figure 3~4
Figure 5~6
AI summary
The present invention provides a method and a system for collecting a fluorescence spectrum of an analyte, and a medium, and a device, which relate to the field of optical analysis. The method includes: irradiating and imaging a first area by infrared light to obtain a first image; dividing the first area into a testing point candidate area and a reference point candidate area based on grayscale distribution indicates uneven distribution of the analyte; irradiating and imaging the first area by ultraviolet light based on an excited fluorescent radiation signal, to obtain a second image; and based on a grayscale value selecting a testing point from the testing point candidate area, and collecting fluorescence spectral data of the testing point; and selecting a reference point from the reference point candidate area and collecting fluorescence spectral data of the reference point.