Fluorescence Image Correction with Error Region Detection

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Solution Overview

Problem

Fluoroscopy apparatuses face challenges in accurately correcting fluorescence images due to varying observation distances, leading to errors in lesion region detection, as existing methods fail to adequately normalize luminance values and account for image-acquisition conditions.

Innovation Solution

A fluoroscopy apparatus that includes a light source unit for generating illumination and excitation light, a fluorescence-image generating section, a return-light-image generating section, a fluorescence-image correcting section for normalizing luminance values, an error-image identifying section to standardize image-acquisition conditions and identify error regions, and an image display unit to display error regions, thereby correcting fluorescence images and improving lesion region observation accuracy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If luminance values are divided by reference-light image to correct fluorescence image, then correction for observation distance variation is achieved, but error regions are not identified and lesion detection accuracy deteriorates

Engineering Contradiction:
Improvefluorescence image correction accuracyVSAvoidlesion region detection reliability
Core Design Contradiction:
Measurement precisionVSReliability

Solution Approach 1:

The system performs feedback by comparing the corrected fluorescence image with the original image, calculating the difference to identify error regions. This feedback mechanism allows the system to detect where correction has introduced errors and where lesion regions may be present, thereby improving both correction accuracy and detection reliability.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The difference image between the corrected fluorescence image and the original image serves as an intermediary that highlights error regions. This intermediary representation allows the system to indirectly detect problematic areas without directly observing the lesion regions, enabling reliable identification through the difference pattern.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Device complexity

If fluorescence image correction is performed without standardizing image-acquisition conditions, then correction process is simplified, but error regions cannot be identified leading to reduced observation accuracy

Engineering Contradiction:
Improvecorrection process complexityVSAvoidlesion region observation accuracy
Core Design Contradiction:
Device complexityVSMeasurement precision

Solution Approach 1:

The system performs preliminary standardization of image-acquisition conditions by capturing a reference-light image under the same conditions as the fluorescence image. This preliminary action establishes a baseline for accurate correction and enables subsequent identification of error regions through comparison, ensuring observation accuracy without excessive complexity.

Inventive Principle:
Principle #10Preliminary action

3Ease of operation

If error regions are not identified and displayed, then the system operates simpler, but lesion regions may be overlooked reducing diagnostic reliability

Engineering Contradiction:
Improvesystem operation simplicityVSAvoidlesion region detection reliability
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The system uses color or intensity changes in the difference image to visually indicate error regions. By representing error regions through distinct visual characteristics (such as highlighted areas or color-coded differences), the system maintains operational simplicity while reliably alerting users to potential lesion regions that require further attention.

Inventive Principle:
Principle #32Color changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The apparatus effectively normalizes fluorescence image luminance values, identifies error regions, and prevents overlooking of lesion regions by displaying error indications, enhancing observation accuracy and prompting reobservation when observation distances are inadequate.

Implementation Method 1

a fluorescence-image generating section that generates a fluorescence image by image-capturing fluorescence generated in the subject by irradiation with the excitation light

Methodology Applied
Scientific EffectFluorescence: Fluorescence

Data Source

PatentUS9332897B2Fluorescence-imaging apparatus
Publication Date: 2016.05.10 OLYMPUS CORPORATION(JP)
  • US9332897B2 patent drawing
  • US9332897B2 patent drawing
  • US9332897B2 patent drawing

AI summary

A fluoroscopy apparatus is adopted which includes a fluorescence-image generating section that generates a fluorescence image of a subject, a white-light-image generating section that generates a white-light image of the subject, a fluorescence-image correcting section that generates a corrected fluorescence image in which luminance values of pixels are normalized by dividing the luminance values of the pixels of the fluorescence image by the luminance values of the pixels of the white-light image, an error-image identifying section that standardizes white-light-image acquisition conditions and identifies an error region, which is a region in which the luminance values of the corrected fluorescence image exceed a preset allowable error range, on the basis of a gray level of the normalized white-light image, and a monitor that displays the error region.