Fluorescence and Visible-Light Image Stitching for Lymphatic Mapping
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Solution Overview
Problem
Existing methods for diagnosing and treating lymphedema lack reproducibility and accuracy, particularly in linking fluorescence imaging with visible light imaging for precise localization of lymphatic fluid accumulation, and there is a need for improved methods and devices to enhance lymphatic function assessment.
Innovation Solution
A method and device that captures and stitches fluorescence and visible light images with a known spatial relationship, using a stitching algorithm to create linked images, allowing for precise localization of lymphatic fluid accumulation and enabling 2D or 3D image reconstruction, and can be used with or without fluorescent agents, exploiting auto-fluorescence.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If fluorescence imaging and visible light imaging are performed separately without spatial linkage, then imaging flexibility is maintained, but diagnostic precision and localization accuracy deteriorate
Solution Approach 1:
The patent combines fluorescence imaging and visible light imaging into a single integrated system with co-registered image capture. The device uses a beam splitter to direct both fluorescence and visible light to the same sensor, enabling simultaneous acquisition of both image types with precise spatial correspondence, thereby achieving high localization accuracy without requiring separate imaging systems
Solution Approach 2:
The patent introduces a beam splitter as an intermediary optical component that separates fluorescence light and visible light paths while maintaining their spatial relationship. This intermediary element enables the simultaneous capture of both image types on the same sensor without requiring complex mechanical coordination or multiple sensors, thus improving precision without proportionally increasing system complexity
2Area of stationary object
If multiple images are captured and stitched together to create large images, then coverage area increases, but processing time and computational complexity increase
Solution Approach 1:
The patent performs preliminary spatial registration and coordinate system alignment during the image capture phase itself. By establishing the spatial relationship between multiple images as they are acquired, the system prepares the data structure for efficient stitching, reducing the computational burden during post-processing and minimizing overall processing time
Solution Approach 2:
The patent uses digital copying and transformation of image coordinates through mathematical operations rather than physical manipulation. The stitching algorithm creates transformed copies of individual images with adjusted coordinates and orientations, efficiently assembling them into large composite images without requiring complex physical repositioning or manual alignment procedures
3Measurement precision
If fluorescent agents are administered to enhance lymphatic fluid visibility, then diagnostic accuracy improves, but patient safety risks and procedural complexity increase
Solution Approach 1:
The patent exploits the natural auto-fluorescence properties of lymphatic fluid itself, eliminating the need for exogenous fluorescent agents. The system captures and processes the inherent fluorescent signal from the lymphatic fluid, providing high-contrast imaging and accurate detection without exposing patients to additional chemicals or dyes, thus improving safety while maintaining diagnostic accuracy
Solution Approach 2:
The patent changes the detection parameter from requiring external fluorescent markers to detecting intrinsic auto-fluorescence signals. By adjusting the imaging system's sensitivity and spectral detection parameters to match the natural fluorescence characteristics of lymphatic fluid, the system achieves high detection accuracy using the body's own fluorescent properties, avoiding the need for exogenous agents and their associated risks
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Provides enhanced diagnostic precision and reliability for lymphedema, allowing for objective assessment and tailored therapy by linking fluorescence and visible light images, improving the accuracy of lymphatic function assessment.
Implementation Method 1
capturing a fluorescence image by illuminating the tissue with excitation light having a wavelength suitable to generate emitted light by excited emission of the fluorescent agent
Data Source
Figure 1
Figure 2
Figure 3a~4
AI summary
An image capturing and processing device (2) configured to measure a fluorescence signal in a tissue of a body part (4), to which a fluorescent agent (8) has been added, and to image a surface (11) of the body part (4). The device (2) comprising an illumination unit (16), a fluorescence imaging unit (22) and a visible light imaging unit (24). The fluorescence imaging unit (22) and the visible light imaging unit (24) are configured in that a viewing direction and/or a perspective of the fluorescence image and the visible light image are linked via a known relationship. A stitching unit (28) applies a stitching algorithm on the visible light images and similarly on the fluorescence images to generate a large visible light image and a large fluorescence image.