Fluorescence Observation Device for Lymphatic Drainage Path Recognition

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Solution Overview

Problem

Conventional lymphedema diagnosis methods, such as scintigraphy, struggle to provide precise local image information and are complex, while existing fluorescence observation techniques lack the ability to effectively visualize lymphatic drainage paths for guiding lymph drainage.

Innovation Solution

A fluorescence observation method and device that involves injecting a fluorescent dye into a living organism, irradiating it with excitation light, and acquiring and processing images to specify a linear fluorescence pattern indicating lymphatic drainage paths, allowing for precise recognition and massage guidance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If scintigraphy is used for lymphedema diagnosis, then diagnostic capability is provided, but local image information of affected limb cannot be obtained and inspection is complex

Engineering Contradiction:
Improvelocal image informationVSAvoidinspection complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The invention extracts and focuses observation on the specific observation object (lymphedema-affected region) from the entire living organism. By specifying and isolating the region containing the lymphedema for targeted fluorescence observation, the system obtains detailed local image information without requiring complex whole-body inspection procedures

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The invention applies local quality by enhancing the observation precision specifically in the lymphedema-affected region through fluorescence imaging. The system provides high-resolution local image information of the affected limb while maintaining simplicity, rather than requiring complex whole-body scintigraphy procedures

Inventive Principle:
Principle #3Local quality

2Measurement precision

If fluorescence observation is performed to observe detailed state of lymphedema, then real-time observation capability is achieved, but ability to precisely recognize lymphatic drainage path is insufficient

Engineering Contradiction:
Improvelymphatic drainage path recognitionVSAvoidlymphatic drainage path information
Core Design Contradiction:
Measurement precisionVSLoss of information

Solution Approach 1:

The invention segments the fluorescence observation process into distinct functional stages: acquiring overall fluorescence distribution, specifying the observation object (lymphedema region), and then acquiring detailed images of that specified region. This segmentation allows systematic extraction and recognition of lymphatic drainage path information from the fluorescence patterns

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The invention performs preliminary action by first acquiring a fluorescence image of the entire living organism to identify and specify the observation object (lymphedema-affected region) before acquiring detailed images. This preliminary specification ensures that subsequent detailed observation focuses on the correct region containing the lymphatic drainage path information

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables precise recognition and facilitation of lymphatic drainage paths from lymphedema-affected areas to the normal lymphatic system, improving the efficiency of lymph drainage treatments.

Implementation Method 1

a wavelength for exciting the fluorescent dye using a light irradiation means (11)

Methodology Applied
Scientific EffectFluorescence: Fluorescence

Data Source

PatentUS10444150B2Fluorescence observation method and fluorescence observation device
Publication Date: 2019.10.15 HAMAMATSU PHOTONICS KK
  • US10444150B2 patent drawing
  • US10444150B2 patent drawing
  • US10444150B2 patent drawing

AI summary

This fluorescence observation method is a method of observing a living organism into which a fluorescent dye is injected. The method includes the steps of: irradiating the living organism with excitation light including a wavelength for exciting the fluorescent dye using a light irradiation means, acquiring a first fluorescence image of the living organism generated by the irradiation with the excitation light using an image acquisition means, specifying an observation object in the living organism on the basis of the first fluorescence image; acquiring a second fluorescence image of the observation object generated by the irradiation with the excitation light using the image acquisition means; and specifying a linear fluorescence pattern appearing in the second fluorescence image.