Fluorescence Measurement Device Position Control
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Solution Overview
Problem
Existing methods for measuring fluorescent substances like AGEs in a non-invasive manner suffer from variations in measurement values due to shifts in the irradiation position of excitation light, leading to unreliable results.
Innovation Solution
A measuring device and system that includes a scanning mechanism with an excitation light irradiation unit and a light receiving unit, coupled with a driving mechanism to control the relative positions, allowing for the acquisition of fluorescence data linked with precise position information, enabling accurate measurement and visualization of fluorescence characteristics across a plane rather than a single point.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If a single-point fluorescence measurement method is used, then the measurement process is simple, but the measurement value varies due to irradiation position shifts
Solution Approach 1:
The patent transitions from single-point measurement to plane measurement by adding spatial dimensions. The excitation light irradiation unit irradiates a plane area rather than a single point, and the fluorescence intensity is measured across multiple positions simultaneously or sequentially, converting a one-dimensional measurement into a two-dimensional spatial measurement to eliminate position-dependent variations.
Solution Approach 2:
The patent divides the measurement area into multiple discrete positions or regions within the irradiation plane. By segmenting the measurement into multiple spatial locations and combining the results, the system achieves position-independent measurement values while maintaining operational simplicity.
2Measurement precision
If the irradiation position is fixed for repeated measurements, then measurement consistency is improved, but the device complexity increases due to positioning control requirements
Solution Approach 1:
The patent makes the measurement system self-correcting by inherently measuring across the entire irradiation plane rather than relying on precise positioning control. The integration of fluorescence signals from multiple positions automatically compensates for position shifts, eliminating the need for complex positioning control mechanisms while maintaining measurement consistency.
3Measurement precision
If plane measurement is implemented to eliminate position variations, then measurement accuracy is improved, but the device complexity increases due to scanning mechanism requirements
Solution Approach 1:
The patent combines the excitation light irradiation function and fluorescence detection function into a single integrated measurement process. By merging these functions and measuring fluorescence across the irradiation plane simultaneously or sequentially without requiring separate scanning mechanisms, the system achieves high measurement accuracy while minimizing device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach eliminates variations in measurement values and provides high-accuracy, two-dimensional data on fluorescent substances, allowing for the visualization of AGEs distribution without additional imaging devices, enhancing the reliability of early diabetes detection.
Implementation Method 1
irradiating a measurement target with excitation light and a light receiving unit for receiving fluorescence generated from the measurement target upon irradiation with the excitation light
Data Source
AI summary
A measuring device (9) of the present invention includes a detector control module (31) for obtaining, from a scanning mechanism including an excitation light source (4) for emitting excitation light and a detector (8) for receiving fluorescence generated from the measurement target upon irradiation with the excitation light, measurement data of the fluorescence, a position information obtaining module (32) for obtaining, from a driving mechanism for controlling relative positions of the scanning mechanism and the measurement target, information of a position where the measurement target is irradiated with the excitation light when the measurement data is obtained, and a fluorescence characteristic management module (33) for preparing fluorescence characteristic data including the measurement data and the position information.